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Two simple spectrophotometric methods have been developed for simultaneous estimation of Rosuvastatin Calcium (RS) and Clopidogrel bisulphate (CP) from tablet dosage form. Method (I) is simultaneous equation method, wavelengths selected are 243 and 230 nm for RS and CP respectively. Method (II) is the absorbance ratio method, based on the determination of graphical absorbance ratio at two selected wavelengths, one being the iso-absorptive point 227 nm and other being the absorption maxima of RS at 243 nm. The linearity ranges for were found RS and CP to be 2-10 ?g/mL-1 and 5-25 ?g/ml respectively. The accuracy and precision were determined and found to comply with ICH guidelines. Both the methods showed good reproducibility and recovery with % RSD in the desired range. The proposed methods can be successfully applied for the routine analysis of both the drugs from tablet dosage form. Proposed method is comparatively cheap and can easily apply for routine analysis.
[Purohit Zalak, Rohit Minal (2014); DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF CLOPIDOGREL BISULFATE AND ROSUVASTATIN CALCIUM IN BULK AND FORMULATION Int. J. of Adv. Res. 2 (2). 0] (ISSN 2320-5407). www.journalijar.com
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