Microbial drug resistance and potential immune response by IL7 and IL10 in burn patients with septic and death cases

Burn injury is one of the critical health problem caused by direct or indirect action of heat. Subsequently, burn injury provides novel sites for bacterial colonization, infection and clinical sepsis. In burn patients serum cytokine levels alter in first 7 days after admission which can be used as predictive markers for identifying patients have high risk of sepsis as well as mortality. A total of 45 blood specimens were collected from patients with burn injury for blood culture. The bacterial pathogen were isolated from blood and tested for antibiotic sensitivity. Also, the sera were used for ELISA to determine the level of cytokines. This study showed that septic and mortality increases with the increase of burn size. It is observed that ciprofloxacin, norfloxacin and amikacin are the most influential on Gram negative bacterial isolates and chloramphenicol, vangomycin and nitrofurantion on Gram positive bacterial isolates. In burn patients, increase in the concentration of IL-7 and IL-10 was observed. Gram negative bacteria found to be more predominant as causative agent for bloodstream infections than the gram positive bacteria in burn injury patient. P. aeruginosa is the most frequent species among bacterial isolates. The presence of endotoxin in septic burn patients might induce IL-7 and IL-10 cytokines production. This study conducted to investigate the role of bacterial infection and their Antibiograms as well as immunological aspects among burn patients.