15Oct 2016

FLOATING DRUG DELIVERY SYSTEMS: RATIONALE FOR DRUG SELECTION.

  • School of pharmaceutical sciences , Jaipur National university.
  • Asso. Professor, school of pharmaceutical sciences, Jaipur National University.
  • Professor, school of pharmaceutical sciences, Jaipur National University.
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In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying time (GET). Several approaches are currently utilized in the prolongation of the GRT. In this review, the current technological developments of FDDS including their drug of choice to be formulated and future potential for oral controlled drug delivery are discussed. The main motto of writing this review article is to compile the information regarding the criteria of drug selection for the floating drug delivery system. In this present review various attempt was made for the discussion of the nature of drug to be selected while formulating floating drug delivery system. Numerous properties of the drug and their mechanism of reaction with polymers was compiled for this study. The various properties of drug such as Biopharmaceutical classification system, Solubility in acidic medium, Partition coefficient, Dissociation constant, Half life, Hepatic clearance, Absorption window, First pass metabolism, Acidic stability, Hydrolysis, Crystallinity of drug, Hydrates form of drug, Irritancy of drug, GI motility, Non Emetic are taken into consideration . With contrast to the various properties of drug molecule, their utilization in the floating drug delivery system is point of concern. The various properties and nature of drug tends to produce an eventual and effective drug delivery system, so that one can understand the basic information for formulating floating drug delivery system.


[Sushil kumar sah , Ajay Kumar Tiwari and B. Shrivastava (2016); FLOATING DRUG DELIVERY SYSTEMS: RATIONALE FOR DRUG SELECTION. Int. J. of Adv. Res. 4 (Oct). 127-133] (ISSN 2320-5407). www.journalijar.com


sushil kumar sah


DOI:


Article DOI: 10.21474/IJAR01/1768      
DOI URL: http://dx.doi.org/10.21474/IJAR01/1768