SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME PHENOLIC MANNICH BASES.
- Sudan University of Science and Technology, Faculty of Science.
- Kordofan University, Faculty of Education.
- Bisha University, Faculty of Science.
- University of Bahri, Faculty of Applied and Industrial Chemistry.
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Four phenolic Mannich bases: 3-(hydroxymethyl)-1-(morpholin-4-ylmethyl)naphthalen-2-yl acetate ;(2-(diethylaminomethyl) phenyl -1 acetate ; 1-[(piperidin-1-yl) methyl]naphthalen-2-ol; N,N-dimethyl-1-(naphthalen-2-yloxy)methanamine were synthesized via a general synthesis protocol involving a single pot facile condensation of an active hydrogen component with a secondary amine in presence of formalin. The constitution of the target molecules was established on the basis of their spectral data(UV, IR, NMR and MS). The Mannich bases were evaluated for their antimicrobial activity using the cup plate agar diffusion method. Compound IV showed excellent antibacterial activity against all test organisms. It was also active against the fungal species Aspergillus niger. The same trend was observed for compound II which showed activity against both fungal species. Compound I demonstrated significant activity against Staphylococcus aureus . Compound III demonstrated different promising antimicrobial responses.
[Abdel Karim. M., Wafa, O., Nafesa. A. G. and Inas. O. (2016); SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME PHENOLIC MANNICH BASES. Int. J. of Adv. Res. 4 (Nov). 928-937] (ISSN 2320-5407). www.journalijar.com
