OXIDATIVE STRESS AND GENETIC INSTABILITIES AMONG PATIENTS WITH CARDIOVASCULAR DISEASE

Cardiovascular disease (CVD) is a leading cause of mortality and is responsible for one-third of all global death in India. CVD will be the largest cause of death and disability by 2020 in India. Oxidative stress (OS) has long been associated with CVD. An increase in reactive oxygen species (ROS) elicited oxidative damage to DNA and other biomolecules may impair normal functions of tissue cells which lead to human aging and CVD disease. Genomic instability at the cellular level can directly affect CVD. The goal of the present study was to evaluate the oxidative stress and genetic instabilities among patients with CVD. Sixty subjects with CVD were selected as study subjects and thirty healthy subjects without any chronic illness were selected as control for the present study. The role of oxidative stress measured by the level of oxidative stress marker, Malondialdehyde (MDA) and the DNA damages were quantified by using Cytokinesis Block Micronuclei (CBMN) Assay. Detailed demographic, clinical and lifestyle characteristics were compared with study subjects. The MDA value and Micronuclei frequency was significantly elevated in the study subjects with that of the control subjects. Although CVD cannot be cured, treatment can help to manage the symptoms and reduce the risk of further problems. CVD can be managed effectively with a combination of lifestyle changes, medicine and, in some cases, surgery.