30Nov 2016

BIOLOGICAL IMPACT OF MORINGA OLEIFERA EXTRACT ON PAROTID GLAND OF CISPLATIN- INDUCED RENAL FAILURE IN ALBINO RATS.

  • Oral Biology Department, Faculty of Dentistry, Mansoura University, Egypt.
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Background:- Cisplatin is a major antineoplasticdrug for the treatment of solid tumors, but it has dose-dependent renal toxicity. Aim:- in the present study we reported the effect of moringa oleifera extract on the parotid gland of cisplatin- induced renal failure of albino rats. Material and methods:- Adult male albino rats were divided into three treated groups and control group of 12 rats each,1. Control rats I, (6 mg /kg body wt. of saline by i.p. injection and repeated after 2 weeks). 2. Study groups (II, III and IV) induction of renal failure done by single i.p. injection of 6 mg /kg body wt. of cisplatin in group III, while in group II and IV this dose was repeated after 2 weeks, 4 days later after the first injection of cisplatin blood samples were collected for creatinine level analysis. In group III after the blood analysis animals received 5 mg /kg body wt. / day of moringa oleifera extract for 2 weeks. In group IV after the second injection of cisplatin, animals received the same dose of moringa oleifera extract for 2 weeks. Animals were sacrificed at 2 intervals, in group I: after 18& 32 days from the start of experiment. In group II: after collection of blood samples&1 week later.in group III and IV at the end of moringa treatment& 1 week later. Results:- Cisplatin administration induced renal failure which was accompanied by increase in serum creatinine level and manifested histologically in parotid gland as cracks like vacuolations, widening of connective tissue septa, loss of acinar outlines and hydropic degeneration. The administration of moringa minimized the cytotoxic effect of cisplatin in group III & IV which was detected by decrease in serum creatinine level, and evidenced histologically as densely packed serous acini with regular basally located nuclei having symmetrical shape and size restoring its normal pattern. Conclusion:- These results suggest that moringa oleifera extract protect against the effect of renal failure on parotid gland.


[Amira A. R. Moawad, Mohammed Abdulrahman Mohammed, Fatma M. Ibrahim and Ahmed R.Zaher. (2016); BIOLOGICAL IMPACT OF MORINGA OLEIFERA EXTRACT ON PAROTID GLAND OF CISPLATIN- INDUCED RENAL FAILURE IN ALBINO RATS. Int. J. of Adv. Res. 4 (Nov). 1620-1627] (ISSN 2320-5407). www.journalijar.com


Amira Ahmed Rizk moawad


DOI:


Article DOI: 10.21474/IJAR01/2253      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2253