30Nov 2016

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF RANITIDINE HYDROCHLORIDE AND DOMPERIDONE IN COMBINED DOSAGE FORM

  • Lecturer; St. John Institute of Pharmacy & Research, Palghar, Mumbai 401 404.
  • Principal; St. John Institute of Pharmacy & Research, Palghar, Mumbai 401 404.
  • Quality Assurance Officer; Impulse Pharma Pvt. Ltd., Boisar, Mumbai 401 506.
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Analysis is important in every product but it is vital in medicines as it involves life. The assurance of quality is achieved through analysis of the drug product. Now days, the pharmaceutical dosage form of combinational drugs are very much useful in multiple therapies, rather than the use of single drug formulation because of multiple action, fewer side effects and quicker relief. Present work is an attempt to develop an accurate, sensitive, reliable and simple RP-HPLC technique for the simultaneous estimation of the drugs Ranitidine Hydrochloride and Domperidone in combined dosage form (Tablet formulation). RP-HPLC method was developed and validated as per ICH guidelines by using Methanol:Water (55:45v/v) pH 3 as mobile phase. Retention time of Ranitidine Hydrochloride and Domperidone were found to be 7.865 min and 2.836 min respectively. The wavelength used was 280 nm and flow rate was 1.0 ml/min. The method was found to be simple, accurate, precise, economical and reproducible. So, the proposed method can be used for the routine quality control analysis of Ranitidine Hydrochloride and Domperidone in tablet formulations.


[Varsha N. More, Savita J. Tauro and Pravin B. Patil (2016); DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF RANITIDINE HYDROCHLORIDE AND DOMPERIDONE IN COMBINED DOSAGE FORM Int. J. of Adv. Res. 4 (Nov). 1405-1421] (ISSN 2320-5407). www.journalijar.com


VARSHA N. MORE


DOI:


Article DOI: 10.21474/IJAR01/2226      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2226