20Dec 2016

A STUDY OF CHANGES IN SERUM CONCENTRATION OF SODIUM, POTASSIUM, CHLORIDE AND MAGNESIUM IN PRE AND POST CISPLATIN AND 5-FLOUROURACIL CHEMOTHERAPY IN HEAD AND NECK CANCER PATIENTS

  • Formerly Consultant Biochemist, Bangalore Baptist Hospital (first author).
  • Asstt. Professor, Department of Biochemistry, Assam Medical College, Dibrugarh, Assam(second author). 1a.Professor and Head, Deptt. Of Biochemistry, Gauhati Medical College, Guwahati(first author
  • Demonstrator, Deptt. Of Biochemistry, Assam Medical College, Dibrugarh, Assam.
  • Demonstrator, Deptt. Of Biochemistry, Assam Medical College, Dibrugarh.
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A clinical cross-over study was carried out in a tertiary care hospital in Assam to determine and compare the concentration of serum sodium, potassium, chloride and magnesium in head and neck cancer patients before and after cisplatin and 5-flouro uracil chemotherapy and to find out the impact of cisplatin and 5-flouro uracil in serum sodium, potassium, chloride and magnesium concentration in head and neck cancer patients. The present study was conducted in the department of Biochemistry, in collaboration with the department of Otorhinolaryngology, Assam Medical College and Hospital. Fifty (50) patients having histologically proved squamous cell carcinoma of head and neck below 70 years of age attending the department of Otorhinolaryngology were taken into account. Values of serum sodium, potassium, chloride and magnesium were compared before and after 1st, 2nd and 3rd cycle of cisplatin and 5-fluorouracil chemotherapy. Mean serum sodium, potassium, chloride and magnesium levels were decreased after all the cycles. Paired t test was performed for statistical analysis. P value (<0.0001) was found to be highly significant. Mean serum creatinine levels were increased after the chemotherapy which is also significant. Our study revealed that hyponatremia, hypochloremia, hypokalemia and hypomagnesemia are the common electrolyte disturbances with cisplatin and 5fluorouracil chemotherapy in head and neck cancer patients. So, close monitoring of renal function and estimation of electrolytes after chemotherapy is recommended.


[Uma Das, Bharati Devi, Kailash Bhattacharyya, Keshab Bora and Pratim Gupta. (2016); A STUDY OF CHANGES IN SERUM CONCENTRATION OF SODIUM, POTASSIUM, CHLORIDE AND MAGNESIUM IN PRE AND POST CISPLATIN AND 5-FLOUROURACIL CHEMOTHERAPY IN HEAD AND NECK CANCER PATIENTS Int. J. of Adv. Res. 4 (Dec). 2617-2624] (ISSN 2320-5407). www.journalijar.com


BHARATI DEVI


DOI:


Article DOI: 10.21474/IJAR01/2684      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2684