20Dec 2016

ACUTE AND SUB-ACUTE ORAL TOXICITY STUDIES OF AQUEOUS EXTRACT OF SECURIDACA LONGEPEDUNCULATA FRESEN (POLYGALACEAE) ROOT BARKS IN RODENTS.

  • Laboratoire de Biologie et Santé Animales/Institut de l’Environnement et de Recherches Agricoles (INERA) Centre National de la Recherche Scientifique et Technologique (CNRST) 04 BP 8645 Ouagadougou 04,Burkina Faso.
  • Laboratoire de Pharmacologie et de Toxicologie/Institut de Recherche en Science de la Santé, (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • Université Ouaga-I Pr Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.
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Securidaca longepedunculata Fresen, (Polygalaceae) is a multi-purpose plant mostly distributed in various tropical African countries, including Burkina Faso. To enable a safe use of the plant, acute and sub-acute toxicity tests of its aqueous root barks extract were undertaken on female NMRI mice and Wistar rats respectively, in accordance with Organization for Economic Cooperation and Development (OECD) test guidelines. In addition to general behavior, adverse effects and mortality recorded for up to 14 days during the acute study, biochemical and morphological parameters were also determined in subacute toxicity assays. In the oral acute toxicity assay, the aqueous extract of the plant root barks at dose of 2000 mg/kg b.w. induced mortality of mice. However, no mortality of mice were observed at dose of 300 mg/kg b.w. The LD50 value estimated was 1000 mg/kg b.w. In the 28 days sub-acute oral toxicity study in Wistar rats, there was no mortality observed at doses of 50, 100 and 200 mg/kg/day. Furthermore, this subacute treatment did not induce any noticeable changes in body weight gain, food and water consumption and biochemical pro?les in animals. In addition, no changes in macroscopical aspect of organs were observed. These results showed that acute administration of root barks aqueous extract of S. longepedunculata displays slightly toxicity in female mice, while subacute administration did not cause any toxic effect in Wistar rats. This suggested a safe use of the S. longepedunculataroot barks based remedies for human or veterinary medicines.


[Almamy Konate, Geoffroy G. Ouedraogo, Sylvain Ilboudo, Noufou Ouedraogo, Adama Kabore, Amadou Traore, Innocent P. Guissou and Hamidou H. Tamboura. (2016); ACUTE AND SUB-ACUTE ORAL TOXICITY STUDIES OF AQUEOUS EXTRACT OF SECURIDACA LONGEPEDUNCULATA FRESEN (POLYGALACEAE) ROOT BARKS IN RODENTS. Int. J. of Adv. Res. 4 (Dec). 550-558] (ISSN 2320-5407). www.journalijar.com


Almamy Konaté
Laboratoire de Biologie et Santé animales/Institut de l’Environnement et de Recherches Agricoles (INERA) Centre National de la Recherche Scientifique et Technologique (CNRST)

DOI:


Article DOI: 10.21474/IJAR01/2429      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2429