ANTIOXIDANTPROPERTIES AND HEPATOPROTECTIVE EFFECT OF ANDROGRAPHIS PANICULATAON PCM INDUCED HEPATOTOXICITY IN ALBINO RATS.
- Department ofKayachikitsa faculty of Ayurveda IMS, BHU,Varanasi.
- Centre of Experimental Medicine &surgery,IMS, BHU Varanasi.
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Methanolic extract ofAndrographispaniculata was evaluated for hepatoprotective and antioxidant activities in albino rats. The plant extract (250 and 500 mg/kg, bw.) exhibited a remarkable hepatoprotective and antioxidant activity againstparacetamol induced hepatotoxicity as judged from the serum marker enzymes and antioxidantlevels in liver tissues. Paracetamol induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), lipid peroxidase(LPO) and bilirubinwith a reduction of protein, superoxide dismutase (SOD). Treatment of rats with different doses of plant extract(250 and 500 mg/kg) significantly (P<0.001) alteredserum marker enzymes and antioxidant levels to near normal againstparacetamol induce albino rats. The activity of the extract at dose of 250 mg/kg was comparable to more effective than dose of 500, mg/kgbw.). Histopathological changes of liver sample were compared with respective control. Results indicate the hepatoprotective and antioxidant properties of Andrographispaniculataagainstparacetamol -induced hepatotoxicity in albino rats.
[Singh Aakansha and SinghS. K. (2016); ANTIOXIDANTPROPERTIES AND HEPATOPROTECTIVE EFFECT OF ANDROGRAPHIS PANICULATAON PCM INDUCED HEPATOTOXICITY IN ALBINO RATS. Int. J. of Adv. Res. 4 (Dec). 1415-1420] (ISSN 2320-5407). www.journalijar.com
Department of kyachikitsa faculty of Ayurveda IMS BHU Varanasi.