20Jan 2017

DIAGNOSTIC VALUE OF CONVENTIONAL CYTOGENETIC ANALYSIS IN SELECTED CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER.

  • Pediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. Psychiatry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
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Introduction: Attention deficit hyperactivity disorder (ADHD) is a wide spread, highly heritable, disruptive, childhood-onset condition, the etiology and pathogenesis of which is poorly understood. ADHD in children have been associated with several cytogenetic aberrations. The most remarkable of these include; sex chromosome aneuploidies, fragile X syndrome, velocardiofacial syndrome, certain balanced translocations, and others. Some researchers have suggested that cytogenetic analysis should be considered in children with ADHD. However, most evidence to date suggests that these abnormalities are found with increased frequency in ADHD children with positive family history or abnormal clinical signs. Objective: The main goal of this study is to assess the potential diagnostic value of conventional cytogenetic analysis (karyotyping) in ADHD children with positive family history and / or abnormal clinical signs. Method: Blood samples were obtained from 19 ADHD children (13 boys) with positive family history and / or abnormal clinical signs, and analyzed for the presence of cytogenetic abnormalities using high resolution chromosomal banding. Results: three cases had chromosomal abnormalities. Two of them had numerical sex chromosome abnormalities; one had Klinefelter syndrome (47, XXY), while the other had triple X syndrome (47, XXX). The third case had balanced translocation as follow; [46,XY,t(4;21)(p16;q22.1)]. By comparing these findings with their respective prevalence among live births, there was highly significant statistical difference, which indicates high diagnostic value of karyotyping with these selection criteria. Conclusions: In the presence of abnormal clinical signs or positive family history, the cytogenetic assessments are indicated for children with ADHD as a component of investigations of this disorder.

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[Mohamed Abdel Malik Hassan, Ali Alnabawy and Shaimaa Abdelmalik Pessar. (2017); DIAGNOSTIC VALUE OF CONVENTIONAL CYTOGENETIC ANALYSIS IN SELECTED CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER. Int. J. of Adv. Res. 5 (Jan). 639-646] (ISSN 2320-5407). www.journalijar.com

Shaimaa Abdelmalik Pessar
lecturer of clinical pathology, Faculty of medicine, Ain Shams university

DOI:

Article DOI: 10.21474/IJAR01/2792      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2792

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