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Introduction: Calcium (Ca), which is an essential factor for human life, could play a role in pathophysiology of spontaneous intracerebral hemorrhage (ICH). This prospective study was conducted to assess serum Ca level in a cohort of Egyptian patients with ICH and searching for a possible association between serum Ca and both of hematoma volume and short-term outcome after ICH. Patients and Methods: This study was conducted at intensive care units (ICU) of neurology department, Zagazig University Hospitals, Egypt. We included ninety patients with spontaneous ICH. All patients were subjected to thorough history taking, general and neurological examination. National Institute of Health Stroke Scale (NIHSS) was done on admission to assess stroke severity. Initial Computed Tomography (CT) scans were done for all patients within the first 24 hours of admission to calculate the hematoma volume. Serum Ca level was measured on admission for all patients. Short-term outcome was assessed using the modified Rankin scale after one month of ICH onset. Results: Among the ninety cases of ICH, (14.4%) had low serum Ca on admission. Patients with low serum calcium level had a significantly larger initial hematoma volume and higher scores on NIHSS in comparison to ICH patients with normal Ca level. Serum Ca was inversely correlated with hematoma volume (p<0.001), stroke severity (P<0.001) and stroke outcome according to modified Rankin scale. Conclusion: low serum Ca level on admission was associated with large initial hematoma volume and unfavorable outcome in patients with spontaneous ICH.
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[Mamun Sarhan, Nahed Shehta, Bothina M. Ramadan and Tamer S. El-Serafy. (2017); PROGNOSTIC SIGNIFICANCE OF SERUM CALCIUM LEVEL IN A SAMPLE OF EGYPTIAN PATIENTS WITH INTRACEREBRAL HEMORRHAGE. Int. J. of Adv. Res. 5 (2). 207-213] (ISSN 2320-5407). www.journalijar.com
neurology department, Zagazig university, Egypt
Article DOI: 10.21474/IJAR01/3133 DOI URL: http://dx.doi.org/10.21474/IJAR01/3133
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