21Feb 2017
PEDIATRIC CASE OF ACCIDENTAL ORAL OVER DOSE OF METHOTREXATE.
- Pediatrics Department, King Fahad of The University Hospital, Khobar,Kingdomof Saudi Arabia.
- Abstract
- References
- Cite This Article as
- Corresponding Author
We present the second youngest reported case of a single oral overdose of methotrexate inotherwise well 19 month sold child. Initialhistory revealed possibleingestion of 10 tablets, eachcontaining 2.5 mg. The peakmethotrexate levelwas. 92mmol/L measured8 hourfollowingingestion.
- Schillie SF, Shehab N, Thomas KE, Budnitz DS. Medication overdoses leading to emergency department visits among children.Am J Prev Med. 2009 ;37(3):181-7.
- LoVecchioF,Katz,WattsD,etel.Fouryearexperience withmethotrexate exposures . MedToxicol2008;4:149-50.
- Tuffaha HW, Al Omar Glucarpidasefor the treatmentoflife-threatening methotrexateoverdose. Drugs Today(Barc).2012;84:705-11 .
- OdedraGM,RumackBH(eds):POISONDEX. Englewood,CO:MicromedixInc,1996
- GibbonBN,MantheyDE ."PediatricCaseofAccidentalOral OverdoseofMethotrexate".AnneEmergMed1999;34:98- 100 .
- Hensley MD, Bebarta VS, Borys DJ.A Large Case Series of Acute Pediatric Methotrexate Ingestions.PediatrEmerg Care. 2016 ;32(10):682-684 .
- MeyerS,EddlestonM,BailyB,DeselH,GottshlingS, GorterL.UnintentionalHouseholdPoisoninginChildren . KlinPediatr.2007;219(5):245-70 .
- VanderMeerA,WulffraatNM,PrakkenBJ,GijsbersB, RademarkerCM,SinnemaG.PsychologicalSideEffectsofMTXTreatmentinJuvenileIdiopathicArthritis.ClinExpRheumatol.2007;25(3):480-5 .
- AdvancesinIndividualPredictionof MethotrexateToxicity. BrJHaematol.2009;146(5):489- 503 .
- Toxbase,UK hhtp://toxbase.org/Poisons-index-A-Z/M-Products/Methotrexate.
- ShirazB,SokLK,MuniasamyS."Accidantalmethotrexate ingestionina19-month-oldchild"BMJ Case Rep. 2011;2011. bcr1120103477.
- Chabner BA , Young RC. Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues . J Clin Invest 1973;52:1804-1811 .
[Mohammed Almadan, Hedayah Hodayah and Ghufran Hodyah. (2017); PEDIATRIC CASE OF ACCIDENTAL ORAL OVER DOSE OF METHOTREXATE. Int. J. of Adv. Res. 5 (Feb). 1144-1147] (ISSN 2320-5407). www.journalijar.com
Mohammed Almadan