21Feb 2017

VAGINAL MALIGNANT MELANOMA IN TREATED PATIENT OF CARCINOMA CERVIX- AN UNUSUAL CLINICALENTITY.

  • Department of Radiotherapy, PGIMER, Chandigarh.
  • Department of Cytopathology, PGIMER, Chandigarh.
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  • Abstract
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Vaginal melanoma is a rare gynecological malignancy, with no clearly defined risk factor. It presents mostly in postmenopausal women as a painless lump in lower vagina. Surgical excision with or without adjuvant radiotherapy is the treatment of choice. Despite all treatment modalities, it is characterized by its poor survival outcome. There isn’t yet any conclusive evidence on the possibility of radiation induced carcinogenesis.


  1. A.Weinstock, “Malignantmelanoma of the vulva and vagina in theUnited States: patterns of incidence and population-based estimates of survival,” The American Journal of Obstetrics andGynecology, vol. 171, no. 5, pp. 1225–1230, 1994.
  2. -N. Hu, G.-P.Yu, and S. A. McCormick, “Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas,” Melanoma Research, vol. 20, no. 2, pp. 153–158, 2010.
  3. Gupta D, Malpica A, Deavers MT and Silva EG: Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. Am J SurgPathol 26: 1450?1457, 2002.
  4. Miner TJ, Delgado R, Zeisler J, et al: Primary vaginal melanoma: a critical analysis of therapy. Ann SurgOncol 11: 34?39, 2004.
  5. Borazjani, K. A. Prem, T. Okagaki, L. B. Twiggs, and L. L. Adcock, “Primarymalignant melanoma of the vagina: a clinicopathological analysis of 10 cases,” Gynecologic Oncology, vol. 37, no. 2, pp. 264–267, 1990.
  6. https://cancerstaging.org/references-tools/quickreferences/documents/melanomasmall.pdf
  7. Abramova, J. Parekh, W. P. Irvin Jr. et al., “Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review,” Annals of Surgical Oncology, vol. 9, no. 9, pp. 840–846, 2002.
  8. Frumovitz M, Etchepareborda M, Sun CC, et al: Primary malignant melanoma of the vagina. Obstetrics and Gynecology 116: 1358?1365, 2010.
  9. J. Ives, R. L. Stowe, P. Lorigan, andK.Wheatley, “Chemotherapy compared with biochemotherapy for the treatment ofmetastatic melanoma: a meta-analysis of 18 trials involving 2,621 patients,” Journal of Clinical Oncology, vol. 25, no. 34, pp. 5426– 5434, 2007.
  10. Harting MS and Kim KB: Biochemotherapy in patients with advanced vulvo-vaginal mucosal melanoma. Melanoma Res 14: 517?520, 2004
  11. Androutsopoulos G, Adonakis G, Ravazoula P, Kourounis G. Primary malignant melanoma of vagina: A case report. Eur J GynaecolOncol 2005;26:661?
  12. Tjalma WA, Monagham JM, de Barros Lopes A, Naik R, Nordin A. Primary vaginal melanoma and long term survivors. Eur J GynaecolOncol 2001;22:20?
  13. C. Reid, R.W. Schmidt, J. A. Roberts, M. P.Hopkins, R. J. Barrett, andG.W.Morley, “Primarymelanoma of the vagina: a clinicopathologic analysis,” Obstetrics and Gynecology, vol. 74,no.2 pp. 190–199, 1989.
  14. Jhappan C., Noonan Frances P and Merlino G. Ultraviolet radiation and cutaneous malignant melanoma. Oncogene (2003) 22, 3099–3112
  15. Korcum A Fidan, Sanlioglu S, Aksu Get al. Radiotherapy-induced decreases in substance P levelsmay potentiate melanoma growth. Molecular medicine reports 2: 319-326, 2009.

[Divyesh Kumar, Anindya Mukherjee, Manish Rohilla, Nalini Gupta, Bhavana Rai and Sushmita Ghoshal. (2017); VAGINAL MALIGNANT MELANOMA IN TREATED PATIENT OF CARCINOMA CERVIX- AN UNUSUAL CLINICALENTITY. Int. J. of Adv. Res. 5 (Feb). 1158-1161] (ISSN 2320-5407). www.journalijar.com


Anindya Mukherjee


DOI:


Article DOI: 10.21474/IJAR01/3268      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3268