CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT NEOPLASMS AND IN THE ELDERLY.

Introduction: Congenital abnormalities of the kidneys and urinary tract represented a spectrum of malformations often grouped under the acronym for CAKUT. Normal development of the kidneys and urinary tract is the result of the precise interaction, spatially and temporally coordinated, between two structures, the metanephric mesenchyme (which originates from the nephrogenic cord) and the ureteric bud (which originates from nefrico duct or Wolff). Any alteration, it's genetic, environmental, or stochastic, which influence this process can result in kidney malformations and streets urinariedel present study is to evaluate in relation to clinical attention the incidence of risk in neoplastic 'association cancer and malformation. in adults Materials end Methods: Male patient of 75 suffering from gross hematuria and hernia inquinale sn accompanied by dysuria symptoms, in heavy smoker instrumental ultrasound examination of the urinary tract showed a solid lesion in the posterolateral wall sn aggittante in the bladder lumen The uro-CT examination showed a " abnormality of the urinary tract development with ectopia crusade and merger of the two kidneys located alongside sn (fot, 3.4) of the renal pelvis are addressed before the district complete with double ureteral sn .In at the urethral meatus will highlight a focal thickening protruding into the lumen wall to finely irregular margins, with enhancement after contrast medium. (photo 5.6) the CT examination conducted in the chest (photo 7) confirmed the marked signs of emphysema, the anterior segment of the left upper lobe, in close relationship with bronchus and vessels segmented solid training in margins lobed (29x20 mm axial diameter approximately). At PET-CT accumulation of the tracer in the upper field of the left lung in the paramedian attributable to non-specific reactive process .Fig (8.9), then he performed genetic test that confirmed mutations in the PAX2 Results: The UroCT is the imaging examination with greater sensitivity and specificity. The limit lies in the poor ability to detect flat lesions non-invasive muscle. The urography has been almost entirely supplanted by UroTC. The current biomarkers do not have a sensitivity and specificity greater than urinary cytology, and The aromatic amines, NAT2 and NAT1 of tobacco smoking products, are considered the main cause of the vescica.la flexible cystoscopy cancer (Narrow Band Imaging) is being promoted as first-invasive test to be practiced in the patient suspected of having a bladder tumor. Uro-RM, similarly to what happens with the urography and CT, it is possible the study of the urinary tract, in order to seek sincrone. l'associazione urothelial lesions and tumors in malformations has prompted our research towards an evaluation genetics through genetic testing the result of which was the presence of a mutation in the PAX2, Discussion: Renal abnormalities, according to the classification of Ridson, are divided into: number of anomalies, seat of anomalies, anomalies of form, abnormalities of differentiation, The presence of a double district pyelo-ureter. Observed in the patient was incomplete, with the two ureters who join before leading into the bladder through a common orifice, Figure 3 also the duplicity era asymptomatic, and was accompanied by a fusion anomaly: a horseshoe kidney. It was also present malrotation renaleuna genetic evaluation by performing genetic tests given to the search for possible correlation between cancer and malformation with oncological risk assessment identifies a heterogeneous set of tests designed to identify changes in the DNA sequences of the germline or of the products that are derived directly from the modification of transmissible genomic sequences .. the geographical correlation allows altresi to compare health risk levels allows you to answer the question whether there is a relationship between risk of death or birth defects as evidenced by numerous studies there is a risk increased cancer and malformations in the presence of high socioeconomic deprivation With increasing environmental pressure has been a steady trend in the health risk Conclusions: Genetic testing can predict with great accuracy the future development of the health of a single individual in the presence of defects is necessary to provide genetic testing for the purpose of assessing the health of the individual. You can assume the major socio-ethical-legal implications for presymptomatic testing, the only genetic tests that can predict with certainty and in the future occurrence of a disease tests for clinical purposes provide information on the health status of subject. Those carried out for research purposes usually generate information that is not indicative of health status or genetic risks of the subject, but it is useful for the purposes of statistical or scientific researc: