22Apr 2017

BIOAVAILABILTY STUDY OF NICARDIPINE LIQUISOLID COMPACT TABLETS IN RABBITS AFTER ORAL ADMINISTRATION.

  • Research Scholar Jawaharlal Nehru Technological University Kakinada, Kakinada, A.P. India.
  • Jangaon Institute Of Pharmaceutical Sciences, Jangaon, Warangal Dist, Telangana, India.
  • University College Of Pharmaceutical Sciences, Warangal Dist, Telangana, India.
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Aim of the present research work is to conduct bio availability study of nicardipine liquisolid compact tablet in rabbit and compare with plain nicardipine drug. Study is conducted by using Randomized Balanced Incomplete Block Design (BIBD) method. Total 8 healthy rabbits were selected with weight of 2.5 kg to 3 kg. Rabbits were labeled by numbers. Each rabbits receiving both formulations after proper wash out period (7 days). Blood samples were collected from marginal ear vein at pre determined time intervals up to 24 Hrs. then blood samples were analyzed by validated high performance liquid chromatography method. Liquisolid compact exhibit c max at 212 ng/ml, t max at 1.63 Hr, AUC (0-t) at 1349 ng.min/ml, AUC(0-∞) at 1403 ng.min/ml and t1/2 at 1.25 hr. AUC and maximum plasma concentration of the liquisolid compact is higher than pure nicardipine drug it indicates liquisolid compacts produce more bioavailability than nicardipine powder.

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[J. Ramesh, B. Vijaya kumar and Y. Narasimha Reddy. (2017); BIOAVAILABILTY STUDY OF NICARDIPINE LIQUISOLID COMPACT TABLETS IN RABBITS AFTER ORAL ADMINISTRATION. Int. J. of Adv. Res. 5 (Apr). 381-389] (ISSN 2320-5407). www.journalijar.com

Ramesh Rishaan
Jawaharlal Nehru Technological University Kakinada, Kakinada, A.P. India.

DOI:

Article DOI: 10.21474/IJAR01/3822      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3822

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