29May 2017

HYPERHOMOCYSTINEMIA IN EPILEPTIC PATIENTS: THE ROLE OF THFR POLYMORPHISM AND ANTIEPILEPTIC DRUGS.

  • Neurology department, Faculty of medicine, zagazig university, Egypt.
  • Clinical pathology department, Faculty of medicine, zagazig university, Egypt.
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Hyperhomocystinemia despite can be seen in small perecentage of normal population but associated with increased vascular diseases in epileptics,hyperhomocystinemia in epileptic patients was supposed to develop primarily from a complex interplay between the chronic intake of enzyme inducing AEDs and genetically determined mutations of MTHFR. Ninety two patients with epilepsy between the ages of 18 and 40 years consented to participate in the study in order to study analyses the effect of a C677T polymorphism of MTHFR and AEDs on tHcy levels in patients with epilepsy treated for at least 6 months with monotherapy including the traditional and newer AEDs.


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[Nesma A.M. Ghonimi, Mohammed E. Mahdy, Tamer S. Elserafy, Nora S. Abdelrahman and Bothina M. Ramadan. (2017); HYPERHOMOCYSTINEMIA IN EPILEPTIC PATIENTS: THE ROLE OF THFR POLYMORPHISM AND ANTIEPILEPTIC DRUGS. Int. J. of Adv. Res. 5 (5). 1644-1649] (ISSN 2320-5407). www.journalijar.com


Mohammed E. Mahdy
Neurology lecturer

DOI:


Article DOI: 10.21474/IJAR01/4293       DOI URL: http://dx.doi.org/10.21474/IJAR01/4293


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