15Jun 2017

THE ANTI-INFLAMMATORY EFFECTS OF TAIF PUNICA GRANATUM IN CYTOKINES PRODUCTION IN PBMCS OF PATIENTS WITH RHEUMATOID ARTHRITIS (RA).

  • Biotechnology Department, Faculty of Science, Taif University, 888-Taif, Kingdom of Saudi Arabia.
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Aim: Punica granatum L., generally known as pomegranate has been used for thousands of years to cure a wide range of diseases including rheumatoid arthritis (RA). This study examines Punica granatum extracts effect on cytokines production in PBMCs of patients with Rheumatoid arthritis (RA). Materials & methods: PBMCs were treated by 5?200 μg/ml of P. granatum methanol, aqueous, acetone, ethyl acetate extracts in realse of IFN-γ, IL-10, IL-4, and TGF-β cytokines using ELISA. Results: Methanol and aqueous P. granatum extracts suppressed IFN-γ release and enhanced IL-4 and IL-10 production, all the extracts enhanced the production TGF-β from PBMCs of patients with Rheumatoid arthritis (RA). Conclusion: Following treatment with P. granatum extracts cyto?kine production showed decrease of IFN-γ release which is proinflammatory mediator, also raise of IL-4 and IL-10 production. It is also significantly increases TGF-β release which is anti-inflammatory cytokine.


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[Albogami Sarah. (2017); THE ANTI-INFLAMMATORY EFFECTS OF TAIF PUNICA GRANATUM IN CYTOKINES PRODUCTION IN PBMCS OF PATIENTS WITH RHEUMATOID ARTHRITIS (RA). Int. J. of Adv. Res. 5 (Jun). 448-455] (ISSN 2320-5407). www.journalijar.com


Sarah.Mohammad.Albogami
Biotechnology Department, Faculty of Science, Taif University, 888-Taif, Kingdom of Saudi Arabia

DOI:


Article DOI: 10.21474/IJAR01/4431      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4431