20Jul 2017

ENCAPSULATION OF VENLAFAXINE HCL IN TO POLY-E-CAPROLACTONE MICROSPHERES BY W/O/W AMD W/O/O EMULSION SOLVENT EVAPORATION TECHNIQUE AND COMPARISON FOR ITS CONTROLLED RELEASE PROPERTIES.

  • M. Pharm., Department of Pharmaceutics, Girijananda Institute of Pharmaceutical Sciences, Azara, Guwahati, Assam-781017, India.
  • Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati-781017, India.
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Objective: The objective of the proposed work was to investigate the method for the efficient encapsulation of highly water soluble venlafaxine hydrochloride into poly-e-caprolactone microspheres by water-in-oil-in-oil and water-in-oil-in water double emulsification technique and comparison for its controlled release properties. Method: The Venlafaxine loaded microspheres are prepared by water-in-oil-in-oil (w/o/w) and water-in-oil-in water (w/o/o) double emulsification technique. The compatibility study of drug with polymer was performed by Differential scanning caloriemetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The prepared microspheres are studied for their particle size, drug entrapment efficiency. The microspheres are characterised by SEM and in-vitro release of Venlafaxine was studied in phosphate buffer pH 1.2 for 12 hours and further studied for kinetic modeling. Result: The precentage yield of Venlafaxine loaded microspheres of all the formulations were found better by w/o/w method(92.21% for F 3). The particle size was found in a range of 130-135 μm and 120-125 μm for both W/O/W and W/O/O formulations. The entrapment efficiency was found in F 5 formulation prepared by W/O/O method. While the in-vitro release of Venlafaxine showed a drug release below 60% after 12 h of study whereas the marketed formulation released above 90% within 6 h and the mechanism was found to be fickian type. Conclusion: The prepared poly-ε-caprolactone microsphere is capable of delivering Venlafaxine HCl over prolonged periods, making it a potential candidate for controlled drug delivery.


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[Manabendra Rabha and Bipul Nath. (2017); ENCAPSULATION OF VENLAFAXINE HCL IN TO POLY-E-CAPROLACTONE MICROSPHERES BY W/O/W AMD W/O/O EMULSION SOLVENT EVAPORATION TECHNIQUE AND COMPARISON FOR ITS CONTROLLED RELEASE PROPERTIES. Int. J. of Adv. Res. 5 (Jul). 836-842] (ISSN 2320-5407). www.journalijar.com


Manabendra Rabha
Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati-781017, India

DOI:


Article DOI: 10.21474/IJAR01/4787      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4787