FORMULATION AND EVALUATION OF MATRIX TABLETS OF NIFEDIPINE BY USING HYDROPHOBIC AND HYDROPHILIC POLYMER.

Objective: The aim of the present research is to formulate and evaluate matrix tablet of Nifedipine by using hydrophobic and hydrophilic polymer. Method: The Nifedipine matrix tablets were prepared by wet granulation method. Formulated tablets were characterized by parameters like hardness, friability, content uniformity, weight variation and in- vitro release studies. In vitro drug release studies were carried in dissolution apparatus using 900 ml of 0.1N HCL (pH 1.2 buffer) for first 2 hours and remaining 12 hours in phosphate buffer (pH 6.8) containing 1% w/v sodium lauryl sulfate as dissolution medium. The amount of drug released was determined spectrophotometrically at 235 nm. Result: The results of the present study based on the in- vitro dissolution studies showed that formulation F5 was shown drug release upto 92.53% at 14 hours was selected as the best formulation from Nifedipine formulations. All the formulated tablets were evaluated for various physical parameters such as hardness, thickness, friability weight variation and drug content was found to be within the limit. In selected formulation, the calculated regression coefficients for drug release kinetics follows the Korsemayer-peppas and drug transport mechanism follow anomalous transport and non- fickian diffusion mechanism release. Conclusion: The result of the study demonstrated that combination of both hydrophilic and hydrophobic polymers could be successfully employed for formulating sustained-release matrix tablets of nifedipine.