17Jul 2017

MICROWAVE ASSISTED SYNTHESIS OF SOME SUBSTITUTED 2-PYRAZOLINE - A GREEN APPROACH.

  • Department of Chemistry, P.M.B. Gujarati Science College, Indore (M.P.).
  • Department of Chemistry, Govt. Madhav Science P.G. College, Ujjain (M.P.).
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Microwave assisted synthesis of chalcones under solvent-free conditions resulted in a ?green chemistry? procedure for the preparation of 2-pyrazoline derivatives in very good yields. 1-Thiocarbamoyl-3,5-diphenyl-2-pyrazoline was synthesized by the MWI of a mixture of corresponding chalcone, thiosemicarbazide and NaOH in ethanol in modified domestic microwave oven and characterized on the basis of elemental analysis, molecular weight determination and spectral data like 1H-NMR, IR. These compounds were screened for their antibacterial activity against gram positive and gram negative bacteria.

  1. Khan S. A., Asiri A. M., Kumar S. and Sharma K., (2014), Green synthesis, antibacterial activity andcomputational study of pyrazoline and pyrimidine derivatives from 3-(3, 4-dimethoxy-phenyl-1-(2, 5- dimethyl-thiophen-3-yl)-proenone, J. Chem., 5(1), 85-90.
  2. Dhindsa K. S., Dudeja M., Malhotra R. and Gupta M. P., (1993), Synthesis and characterization of Co (II), Ni(II) and Co (II) complexes of 1-acetyl-5-aryl-3-(substituted thienyl)-2-pyrazolines and their microbiocidal activity, Indian J. Chem., 32A, 975-979.
  3. Sangwan N. K., Singh N. and Dhindsa K. S. (2000), Synthesis and fungitoxic activity of 5-aryl-1-formyl-4, 5-dihydro-3-(2-hydroxyphenyl)-1H-pyrazoles and their complexes, Manag. Sci., 56, 284-288.
  4. Ozdemir Z., Calis U., Bilgin A. A., Kandilci H. B. and Gumusel B., (2007), Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives, J. Med. Chem., 42(3), 373-379.
  5. Abdel-Aziz M., El-Din A., Abuo-Rahma G. and Hassan A. A., (2009), Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant actvities, J. Med. Chem., 44, 3480-3487.
  6. Kumar A., Srivastava V. K. and Rani P., (2004) Synthesis and anti-inflammatory activity of heterocyclic indole derivatives, J. Med. Chem., , 39, 449-452.
  7. Al-Jibori M. N., Al-Bayatiand S. M. and Rasheed A. M., (2013), Coordination modes of a new ligand derived from pyrazoline with Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal ions; Synthesis, identification and biological studies, Chem. Mat. Res., 3, 1-12.
  8. El-Wahab Z. H. A., Faheim A. A. and Mashaly M. M., (2005), Synthesis and characterization of cobat(II), cerium (III) and dioxouranium (VI) complexes of 2, 3?dimethyl ?1? phenyl-4-salicylidene-3-pyrazolin-5-one mixed ligand complexes, pyrolytic products and biological activities, Pap., 59, 25-36.
  9. Abu-Surrah A. S., Safieh K. A., Ayoub M. T., Qaroush A. K., Abu?Mahtheieh A. M., Ahmad I. M. and Abdalla M. Y., (2010), New palladium (II) complexes bearing pyrazole-basal schiff base ligands; Synthesis, characterization and cytotoxicity, J. Med. Chem., 45, 471-475.
  10. Saleem K., Wani W. A., Haque A., Lone M. N., Ali I., Ming-Fa H. and Jairajpuri M. A., (2013), Synthesis, DNA binding, hemolysis assays and anticancer studies of copper (II), nickel (II) and iron(III) complexes of a pyrazoline-based ligand, Future Med. Chem., 5, 135-146.
  11. Dasary K., Lavania A., Yadav M. and Anand A. V. K., (2013), Synthesis, characterization and study of antioxidant activities of some new pyrazoline derivatives containing Isatin moiety, J. Res. Engin. Sci., (IJRES), 1(7), 08-13.
  12. El-Sabbagh O. I., Baraka M. M., Ibrahim S. M., Pannecouque P., Anderi G., Snoeck R., Balzarini J. and Rashad A. A., (2009), Synthesis and antiviral activity of new pyrazole and thiazole derivatives, J. Med. Chem., 44, 3746-3753.
  13. Budakoti A., Abid M. and Azam A., (2006), Synthesis and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3, 5-diphenyl-2-pyrazoline derivatives and their Pd (II) complexes. J. Med. Chem., 41, 63-70.
  14. Singh P., Negi J. S., Rawat M. S. M. and Pant G. J. N., (2013), Synthesis, antiamoebic activity and thermal study of copper complexes of 1-formyl-2-pyrazolines., Therm. Anal. Calorim., III, 549-552.
  15. Ali M. A., Shaharyar M. and Siddiqui A. A., Synthesis, structural activity relationship and antitubercular activity of novel pyrazolines derivatives, J. Med. Chem., 42(2), 268-275.
  16. Coutinho E. C., Khunt R. K., Khedkar V. M., Chawda R. S., Chauhan N. A. and Parikh A. R., (2007), Synthesis, antitubercular evaluation and 3D-QSAR study of N-phenyl-3-(4-fluorophenyl)-4-substituted pyrazole derivatives, Med. Chem. Lett., 2012, 22(6), 666-678.
  17. R. Strauss, (2009), Aust. J. Chem., 62(1), 3-15.
  18. Varma R. S.,et. al.(2006), Curr. Chem., 266, 199-231.
  19. Shailendra Mandge, et.al.(2007),Synthesis and Characterization of Some Chalcone Derivatives, Trends in Applied Sciences Research, 2, 52-56.
  20. Bhavana Sharma et.al.(2008), Colour Reactions of Chalcones and their Mechanism (A Review), Oriental Journal of Chemistry, Vol.24(1), 289-294.
  21. R. Jaypal et.al.(2010), Anhydrous K2CO3 as Catalyst for Synthesis of Chalcones under Microwave Irradiation, Journal of Pharmaceutical Sciences and Research, Vol. 2(10), 644-647.
  22. M.H. Bhuiyan et.al.(2011), Microwave-assisted Efficient Synthesis of Chalcones as Prob for Antimicrobial Activities, Chemistry Journal, Vol. 1, 21-28.
  23. Vikas Tiwari et.al.(2011), Microwave Assisted Improved Synthesis of Chalcones under Microwave Irradiation and their Antibacterial Activity, Chem. Bio. Phy. Sci., Vol.1, 22-27.
  24. Revathi et.al.(2013), Microwave Assisted Synthesis and Biological Activity of Certain 4-Hydroxy Chalcones, Pharmacophore, Vol.4(2), 59-69.
  25. Davood Azafifar et.al.(2003), Microvave Assisted Synthesis of Some 3,5-Arylated 2-Pyrazoline, Molecules, 8, 642-648.

[Rashmi Sharma and Ajay M. Chaturvedi. (2017); MICROWAVE ASSISTED SYNTHESIS OF SOME SUBSTITUTED 2-PYRAZOLINE - A GREEN APPROACH. Int. J. of Adv. Res. 5 (Jul). 342-346] (ISSN 2320-5407). www.journalijar.com

RASHMI SHARMA

DOI:

Article DOI: 10.21474/IJAR01/4725      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4725

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