28Jul 2017

HEPATOPROTECTIVE EFFECT OF SELENIUM AND TRICHURIELLA MONSONIAE AGAINST CADMIUM INDUCED LIVER TOXICITY IN RATS.

  • Department of Pharmacognosy and Phytochemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, Telangana, India.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Cadmium (Cd) is one of the most common heavy metal pollutant. It is accumulated particularly in liver and kidney. The aim of this work was to study the protective role of combined Selenium and methanolic extract of whole plant of Trichuriella monsoniae against Cd-induced liver toxicity. Male wister albino rats were divided into 9 groups of 4 each and route of administration selected for the study was oral daily for 21 days. Liver damage was induced by administration of Cadmium(5mg/kg CdCl2) and the hepatoprotective activity of the extract and Selenium was assessed on the basis of improvement in the altered levels of various serum biochemical parameters (alanine aminotransferase (ALT), aspartate aminotransferase (AST) alkaline phasphatase (ALP), Gamma-glutamyl transferase (GGT), total bilirubin (TB), direct bilirubin (DB), Cholesterol (CHOL), total proteins (TP) and albumin (ALB) and in the changes occurred in the histology of liver of rats taking Silymarin(100 mg/kg) as standard. Among all the 9 groups tested , the group treated with METM 250 mg/kg in combination with Selenium was found to be effective. The study revealed that the extract in combination with Selenium has shown better activity then the extract alone against Cd induced heptotoxicity in rats which may be attributed to the antioxidant activity of Selenium.

  1. Bagchi, D.M. Bagchi, E.A. Hassoun and Stohs,S.J.(1996): Cadmium induced excreation of urinary lipid metabolites,DNA damage, glutathione depletion and hepatic lipid peroxidation in SpragueDawley rats.Biol. Trace Elements Res., 52: 521-529.
  2. Bagchi, D. Bagchi, M. Stohs, S.J. Ray, .S.D. Kuszynki,C.A. Pruess, H.G.(2000). Free radical and grape seed proanthocyanidin extract: importance in human health and disease prevention.Toxicology., 148: 187-97.
  3. Hans Wedepohl,K. (1995).The composition of the continental crust.Geochimica et Cosmochimica Acta.,59(7):1217-1232
  4. Martelli, A. Rousseelet, C. Dycke,A. Bouron,J. Moulis, M.(2006).Cadmium toxicity in animal cell by interference with essential metals.Biochemie.,88:1807-1814.
  5. Newairy, A.A. El-Sharaky, A.S. Badreldeen, M.M. Eweda, S.M. Sheweita, S.A. ( 2007): The hepatoprotective effects of selenium against cadmium toxicity in rats.Toxicology., 242 (1?3): 23?30.
  6. OECD guidelines for testing of chemicals. Test No: 420: Acute oral toxicity, 17th dec, 2001.
  7. Rajasekaran,A. and M. Periasamy.,2012. Hepatoprotective effect of ethanolic leaf extract of Calycopteris floribunda Lam on Cadmium induced hepatotoxicity in rats. Res j pharma bio chem sci., 3(3), 382-390.
  8. Sandhya, S. Sai, KP. Vinod, KR. Banji, D.? Kumar, K.? Rajeshwar, T.( 2012): In ova angiogenesis analgesic and anti-inflammatory potency of Aerva monsoniae (Amaranthaceae). Asian Pac J? Trop? Dis ., 2: 385?389.
  9. Stohs, SJ. Bagachi, D. Hassoun, E. Baguchi, M.( 2000): Oxidative mechanisms in the toxicity of chromium and cadmium ions. J? Environ Pathol Toxicol? , 20: 77?88.
  10. Swaroopa rani, V. Praneetha, P. Krishna Mohan, G. Ravi kumar, B.( 2001): Antihyperglycemic activity of Trichuriella monsoniae Bennet in streptozotocin induced diabetic rats. Inter J Pharma Educ and Res., 4(4).
  11. Van Acker, FAA. Schouten, O. Haenen, GR. Van Dervijgh, WJF . Bast, (2000): Flavonoids can replace α-tocopherol as an antioxidant. FEBS Lett ., 473:145-8.
  12. Waisberge, M. Joseph, P. Hale, B. Beyersmann, D. (2003): Molecular mechanisms of cadmium carcinogenesis. Toxocology ., 192: 95-11.
  13. Yuan, X. and Tang. (1999): Lead effect on DNA and albumin in chicken of Selenium nutrition. J Environ Sci Health? , 34(9): 1875-1887.

[Divya jyothi P, Praneetha P and Swaroopa Rani V. (2017); HEPATOPROTECTIVE EFFECT OF SELENIUM AND TRICHURIELLA MONSONIAE AGAINST CADMIUM INDUCED LIVER TOXICITY IN RATS. Int. J. of Adv. Res. 5 (Jul). 2224-2230] (ISSN 2320-5407). www.journalijar.com

Swaroopa Rani V
Assistant professor

DOI:

Article DOI: 10.21474/IJAR01/4963      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4963

Download Full Paper

Download PDF No. of Downloads: 46 | No. of Views: 148