24Jul 2017

COMPARATIVE QUALITY EVALUATION OF DIFFERENT OLMESARTAN MEDOXOMIL GENERIC TABLETS MARKETED IN BANGLADESH.

  • Faculty of Medicine, Department of Pharmacy, University of Asia Pacific, 74/A Green Road, Dhaka-1215, Bangladesh.
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The objective of the present study was to evaluate and compare between nine different brands of Olmesartan medoxomil 40mg which are commercially available in Bangladeshi market. We chose nine popular brands, coded them from O1 to O9 and purchased them from local private pharmacies .The physicochemical equivalence of nine brands were determined through the evaluation of both official and non-official standards according to the USP pharmacopoeia including uniformity of weight, thickness, diameter, friability, hardness, disintegration, dissolution rate and drug content. All the tested brands conformed to the official tests for weight variation, friability, disintegration and dissolution tests. The friability test was within the specified limit (except for Brand O2). All formulations disintegrated within 15-30min. The percentage content of active ingredient of almost all brands of Olmesartan medoxomil tablets showed values within the monograph specifications (95-105%). The dissolution profiles showed inter and intra brand variability but all samples attained 75% dissolution within 45mins and complied with USP monograph. The nine brands evaluated in this study could be considered biopharmaceutically and chemically equivalent and it had been determined calculating difference factor and similarity factors. Moreover, the result of all these parameters of different brands were in the pharmacopoeia limits. So it could be concluded that marketed pharmaceutical tablets of Olmesartan medoxomil of these brands are safe, effective and efficacious as well as satisfy quality control limits of pharmacopoeia.. Therefore, patients can safely shift from one brand to another.

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[Tasnova Tasnim and Monirul Hasan. (2017); COMPARATIVE QUALITY EVALUATION OF DIFFERENT OLMESARTAN MEDOXOMIL GENERIC TABLETS MARKETED IN BANGLADESH. Int. J. of Adv. Res. 5 (Jul). 1403-1410] (ISSN 2320-5407). www.journalijar.com

TASNOVA TASNIM
In writing the manuscript

DOI:

Article DOI: 10.21474/IJAR01/4852      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4852

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