20Jul 2017

SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND.

  • Department of Chemistry, Periyar University, Salem-636 011, Tamilnadu, India.
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A series of homo-binuclear Cu(II), Co(II), Ni(II) and Mn(II) metal complexes of Schiff base which was derived from 2,6-diaminopyridine and glyoxal have been synthesized. The plausible geometry of Schiff base and its binucleating metal complexes were examined by means of elemental and thermal analysis, molar conductance, 1HNMR, UV?Vis, IR, ESR and mass spectra. From the spectral studies, a six coordinate environment around the metal dimers was confirmed. Both of the Schiff base and its metal complexes were tested for their in vitro antimicrobial activities against some bacterial and fungal strains. Schiff base and its metal complexes were also investigated for its cytotoxic effect against human breast cancer (MCF7) cell lines and it was observed that homo-binuclear Cu(II) and Co(II) complexes showed a good antitumor activity. The antioxidant activity was measured by DPPH method and the result showed that few metal complexes have been more potential activity.

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[Jayalakshmi Rajendran, Anbarasu Govindharaji, Chozhanathmisra Manickam and *Rajavel Rangappan. (2017); SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND. Int. J. of Adv. Res. 5 (Jul). 1176-1189] (ISSN 2320-5407). www.journalijar.com

Dr. R. Rajavel
Assistant Professor, Department of Chemistry, Periyar University

DOI:

Article DOI: 10.21474/IJAR01/4826      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4826

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