24Jul 2017

COMBINATION EFFECT OF ZIZYPHUS SPINA CHRISTI AND HYPERTHERMIA ON LIVER AND KIDNEY AFFECTED BY EAC IN MICE.

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Loading mice with EAC affect Functions of vital organs specially Liver and Kidney because of these tissues are severely damaged in the animals with EAC cells. The ability of Zizyphus spina Christi (ZSC) fruit extract when combined with hyperthermia to improve the histopathological features associated with Ehrlich Ascites Carcinoma (EAC) stress in experimental mice was assessed. EAC loading mice were treated with hyperthermia or ZSC fruit extract doses (100, 300 mg/ Kg B.W) or with combination between them once/ two days alternatively, for 14 days. Combination treatment of ZSC fruit extract and hyperthermia significantly improve the damage. EAC load had increased the activities of serum GOT and GPT but decreased the concentration of albumin and total protein. Different treatment with hyperthermia or ZSC fruit extract or combination reduced the level of sGPT and sGOT but not significantly. A non-significant increase in the level of serum albumin and total protein was observed too. Moreover, levels of the renal biomarkers, creatinine and urea were highly elevated in EAC-bearing mice, urea level increase after different treatments not significantly where creatinin levels had slight affect except in high dose combination treated group. Taken together, results from this study suggest that addition of ZSC fruit extract to hyperthermia slightly reduce the hepatic and renal damage induced by EAC load in experimental animals.

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[Safwat A Okasha, Fawzia M K Takadom and Mohamed K Hassan. (2017); COMBINATION EFFECT OF ZIZYPHUS SPINA CHRISTI AND HYPERTHERMIA ON LIVER AND KIDNEY AFFECTED BY EAC IN MICE. Int. J. of Adv. Res. 5 (Jul). 1486-1493] (ISSN 2320-5407). www.journalijar.com

Fawzia M K Takadom
Researcher at Nature conservation sector, EEAA

DOI:

Article DOI: 10.21474/IJAR01/4861      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4861

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