26Jul 2017

AMELIORATING EFFECT OF AQUEOUS GARLIC EXTRACT SUPPLEMENTATION ON CADMIUM INDUCED TOXICITY IN ALBINO MICE.

  • Department of Zoology & Environmental SciencesPunjabi University, Patiala-147002, Punjab.
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Cadmium is a highly toxic heavy metal, since it causes deleterious effects in organisms at low levels of exposure. The present study has been undertaken to evaluate the protective efficacy of garlic extract on cadmium induced toxicity in brain and kidney of albino mice. Albino mice were divided into three groups. Group I mice were kept as control. Group II animals were administered a single dose of cadmium chloride (6 mg/kg bw) orally. Group III animals were given a single dose of CdCl2 followed by a chronic dose of garlic extract (100 mg/kg bw) orally. Autopsies were done at the intervals of 15 and 45 days post treatment. A significant elevation in LPO levels with decreased activity levels of SOD, CAT and GST were observed during Cd intoxication at 15 and 45 days post treatment. With garlic supplementation, a significant reversal in the oxidative stress enzymes was observed and also restored the biochemical changes in brain and kidney tissue. It was concluded that garlic prevented the Cd induced toxicity and this might be due to the antioxidant activity of its constituents.


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[Suman Sharma and P. Vijaya. (2017); AMELIORATING EFFECT OF AQUEOUS GARLIC EXTRACT SUPPLEMENTATION ON CADMIUM INDUCED TOXICITY IN ALBINO MICE. Int. J. of Adv. Res. 5 (Jul). 1837-1845] (ISSN 2320-5407). www.journalijar.com


P.Vijaya
DEPARTMENT OF ZOOLOGY & ENVIRONMENTAL SCIENCES PUNJABI UNIVERSITY, PATIALA-147002, PUNJAB.

DOI:


Article DOI: 10.21474/IJAR01/4908      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4908