Evaluation of enzymatic and non- enzymatic antioxidant status in seminal plasma of Iraqi Infertile Men

Abstract: This study was conducted to demonstrate the effect of seminal oxidative stress (OS) on male infertility with different infertility potentials. To achieve this aim, the levels of malondialdehyde (MDA),reduced glutathione (GSH) ,superoxide dismutase(SOD), glutathione peroxi¬dase (GPX) and catalase (CAT) activity in addition to levels of vitamin E and vitamin C were determined in three groups: normospermic who were considered as controls (n=30), asthenospermic (n=27) and oligospermic(n=23).The seminal plasma MDA levels were significantly high in infertile patients (p<0.001)compared to the normospermic subjects ,while GPX, SOD and CAT activities were significantly low in oligospermic and asthenospermic patients respectively in addition ,levels of seminal plasma vitamin E and vitamin C were reduced also significantly in astheno and oligospermic patients compared to normospermic subjects. Our results obviously emphasize the association of OS level in seminal plasma with the incidence and progression of the idiopathic infertility in infertile patients. Thus, seminal reactive oxygen species (ROS) would be used as a specific and sensitive biomarker for idiopathic male infertility. These findings indicate a protective role for antioxidant enzymes of seminal plasma against lipid peroxidation of spermatozoa in normospermic samples.

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[Hasan F.Al-Azzawie, Naeim M and Ehab D.Saleman (2014); Evaluation of enzymatic and non- enzymatic antioxidant status in seminal plasma of Iraqi Infertile Men Int. J. of Adv. Res. 2 (6). 0] (ISSN 2320-5407). www.journalijar.com

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