30Sep 2017

PROTECTIVE EFFECT OF MORINGA OLEIFERA EXTRACT ON EXPERIMENTALLY LPS- INDUCED PERIODONTITIS.

  • BDS, Faculty of Dentistry, Tripoli University, Libya.
  • Lecturer of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt.
  • Professor of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt.
  • Professor of Oral Medicine, Periodontology and Oral Radiology, Faculty of Dentistry, Mansoura University, Egypt.
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Periodontitis (PD) are an inflammatory disorder in which tissue damage occurs through complex interactions between periodontal pathogens and components of the host mechanisms. Natural agents having antimicrobial and anti-inflammatory activities might be able to control the inflammatory diseases such as PD. This study designed to investigate the effect of Moringa Oleifera Extract (MOE) on healing of induced PD. Experimental periodontal disease was induced in rats by injecting LPS in the gingival tissues on the distobuccal aspect of lower first molars (30 ug LPS, 3 times/week for 2 weeks). MOE was administered to rats daily via oral gavage by dose 300 mg/kg once daily. The inflammatory status was evaluated by descriptive analysis of Ob and IL-6 serum level on H&E-stained sections. MOE Group B showed significant decrease in periodontal inflammation. In conclusions: MOE potently inhibits innate immune responses associated with periodontal disease, suggesting a therapeutic potential in this chronic inflammatory condition.

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[Abdulaziz Omar Alshwerf, Laila El Sayed Amin, Fatma Ibrahim and Jilan Youssef. (2017); PROTECTIVE EFFECT OF MORINGA OLEIFERA EXTRACT ON EXPERIMENTALLY LPS- INDUCED PERIODONTITIS. Int. J. of Adv. Res. 5 (Sep). 1734-1740] (ISSN 2320-5407). www.journalijar.com

A. Alaziz Omar Ashwerf
Mansoura university_ Egypt

DOI:

Article DOI: 10.21474/IJAR01/5337      
DOI URL: http://dx.doi.org/10.21474/IJAR01/5337

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