18Sep 2017

MICROWAVE ASSISTED ONE POT SYNTHESIS OF 5-UNSUBSTITUTED-3,4-DIHYDROPYRIMIDIN-2(1H)-ONES UNDER SOLVENT FREE CONDITION:BIGINELLI REACTION.

  • Department of Chemistry, BabuBanarsi Das University Lucknow 226028, India.
  • Department of Chemistry, University of Lucknow, Lucknow 226007,India
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3,4-dihydro-6-(2,4-dihydroxyphenyl)-4-phenylpyrimidin-2(1H)-one (4)has been synthesized by the condensation of 2,4-dihydroxybenzaldehyde, acetophenone and urea with a catalytic amount of ZnI2 under microwave irradiation. In this paper the synthesis, mass spectral analysis and anti inflammatory activities of (3,4-dihydro-6-(2-hydroxyphenyl)-4-phenylpyrimidin-2(1H)-one (1) 6-(4-(dimethylamino)phenyl)-3,4-dihydro-4-phenylpyrimidin-2(1H)-one (2), 3,4-dihydro-6-(3-hydroxyphenyl)-4-phenylpyrimidin-2(1H)-one (3), 3,4-dihydro-6-(2,4-dihydroxyphenyl)-4-phenylpyrimidin-2(1H)-one (4), 6-(3-ethoxy-2-hydroxyphenyl)-3,4-dihydro-4-phenylpyrimidin-2(1H)-one (5), 3,4-dihydro-6-(4-nitrophenyl)-4-phenylpyrimidin-2(1H)-one (6), 6-(2,3-diethoxyphenyl)-3,4dihydro-4-phenylpyrimidin-2(1H)-one (7), 3,4-dihydro-6-(2-hydroxyphenyl)-4-phenylpyrimidin-2(1H)-thione(8), 6-(4-(dimethylamino)phenyl)-3,4-dihydro-4-phenylpyrimidin-2(1H)-thione (9), 3,4-dihydro-6-(2,4-dihydroxyphenyl)-4-phenylpyrimidin-2(1H)-thione (10), 3,4-dihydro-6-(4-nitrophenyl)-4-phenylpyrimidin-2(1H)-thione(11), 6-(2,3-diethoxyphenyl)-3,4-dihydro-4-phenylpyrimidin-2(1H)-thione (12) are beingreported.


  1. Biginelli, P. Chem. Ber.1891, 24, 1317, 2962.
  2. Pechman, H.; Duisberg, C. Ber. 1883, 16, 2119.
  3. Bose, A, K.; Pednekar, S,;Ganguly, S, N,; Chakraborty, G,; Manhas, M, S Tetrahedron Lett. 2004,? 45, 8351.
  4. Wang, Z.; Xu, L.; Xia, C.; Wang, H. Tetrahedron Lett. 2004, 45, 7951-7953.
  5. Biginelli, P. Gazz. Chim. Ital. 1893, 23, 360-362.
  6. Kappe,C.O.; Kumar, D.; Varma, R.S. Synthesis 1999, 10, 1799-1803;
  7. Ashish Kumar Tewari, RashmiDubey, Anil Mishra, Med Chem Res, 2010 DOI 10.1007/s00044-009-9290-9.

[Monika Gupta and Anil Mishra. (2017); MICROWAVE ASSISTED ONE POT SYNTHESIS OF 5-UNSUBSTITUTED-3,4-DIHYDROPYRIMIDIN-2(1H)-ONES UNDER SOLVENT FREE CONDITION:BIGINELLI REACTION. Int. J. of Adv. Res. 5 (Sep). 765-769] (ISSN 2320-5407). www.journalijar.com


MONIKA GUPTA
BABU BANARSI DAS UNIVERSITY LUCKNOW

DOI:


Article DOI: 10.21474/IJAR01/5386      
DOI URL: http://dx.doi.org/10.21474/IJAR01/5386