18Sep 2017

ASSOCIATION AND INTERACTION OF POLYMORPHISMS IN ANGIOGENESIS GENES INVOLVED IN ENDOMETRIOSIS.

  • Dept of Genetics, Vasavi Medical and Research Centre, Khairtabad, Hyderabad- 500 004, Telangana, India.
  • Department of Biochemistry, Nizams Institute of Medical sciences, Hyderabad, Punjagutta, Hyderabad, Telangana, India.
  • Dept of Genetics, University College of Science, Osmania University, Hyderabad-500 007, Telangana, India
  • Dept of Genetics and Molecular Medicine, Kamineni Hospitals, L.B.Nagar, Hyderabad-500 044, Telangana, India.
  • Department of Pathology, JIMS Homeopathic Medical College and Hospital, Sriramnagar, Shamshabad, Telangana, India.
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Endometriosis is a multifactorial disorder where angiogenesis or neo visualization plays an important role in the etiopathogenesis of the disease, which has a prevalence rate of 10-15% in women of reproductive age. Polymorphisms in functionally relevant candidate genes involved in angiogenesis may be important for identifying individuals at high risk of developing endometriosis. Hence, three single nucleotide polymorphisms in Matrix metalloprotienase-2 (rs243865), Matrix metalloprotienase-2-9 (rs3918242) and Intra cellular adhesion molecule-1 (rs1799969) genes were evaluated in individuals with endometriosis and compared with sex and age matched controls.. The present study indicates significant difference in allele distributions of the three SNPs between endometriosis and controls. In the case of ICAM-1 (-G241A) a protective association of GA genotype with endometriosis was seen. Clinical features like dysmenorrhea/pain and infertility were associated with MMP2 and MMP9 polymorphism but ICAM-1 genotypes are directly associated with the pain but not with infertility. According to MDR analysis MMP-2, MMP-9 and ICAM-1 genes were individually contributing their role in causing the disease without interacting with each other. Hence these three SNPs can be used for risk assessment of endometriosis in South Indian population.


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[ M LathaPh.D, S.Govindan Ph.D,S.N.Ahmad Ph.D, S Vaidhya Ph.D,C S MovvaPh.D, V.Kutala PhD, and Q.HasanPh.D and V.KodatiPh.D. (2017); ASSOCIATION AND INTERACTION OF POLYMORPHISMS IN ANGIOGENESIS GENES INVOLVED IN ENDOMETRIOSIS. Int. J. of Adv. Res. 5 (Sep). 880-888] (ISSN 2320-5407). www.journalijar.com


Dr Madhavi latha Manolla
Vasavi Medical and research centre,Nizams Institute of Medical sciences,Jimes Medical Homeopathic hospital and college

DOI:


Article DOI: 10.21474/IJAR01/5402      
DOI URL: http://dx.doi.org/10.21474/IJAR01/5402