ANGIONEUROTIC EDEMA IN A PATIENT WITH HEREDITARY ANGIOEDEMA TYPE I, INDUCED BY AN OPIOID ANALGESIC - A CLINICAL CASE.

Hereditary angioedema (HAE) is a rare disease with different frequencies for different populations. Etiologically the disease is associated with congenital immune deficiencies in the complement system. It is also known that in the pathogenesis of type I HAE leading position occupies the quantitative deficiency of C1-esterase inhibitor (C1-INH). Under the influence of various inducing factors, most commonly injuries, invasive procedures, giving birth, stress and others, is triggered a cascade of reactions leading to the activation of the kinin system, the end result of which is the clinical manifestation of angioedema. Drug-induced edemas were also described in the literature, but their pathogenesis differs from that of HAE. In most cases, behind the induced by taking medication swelling, stand allergic mechanisms. Cases of angioedema induced by other factors and developt by other mechanisms were also described. For participants in the etiology and pathogenesis of angioedema adopt a number of other factors such as irritant, physical, toxic, neuro-reflex agents. In our review of the literature, however, the cases with induced by an opioid analgesic angioedema in patients with proven HAE type I are relatively rare. Therefore we think that the presented clinical case will enrich the knowledge of the etiology and pathogenesis of angioedema and attract the interest of different clinical specialists - allergists, immunologists, ophthalmologists, dermatologists, toxicologists and others.