01Jan 2017

PLASMA AND INTRACELLULAR ERYTHROCYTE ZINC LEVELS DURING PREGNANCY IN BULGARIAN FEMALES WITH AND WITHOUT GESTATIONAL DIABETES

Abstract


Maternal zinc deficiency is often seen during pregnancy. Zinc is a micronutrient whose requirements increase with pregnancy, but Zinc deficiency during pregnancy is common. The purpose of the study was to estimate plasma and intracellular (erythrocyte hemolysate) zinc in pregnant with/without gestational diabetes mellitus (GDM) women, compared to healthy non pregnant. Patients and Methods: The study involved pregnant with GDM (n=45), healthy pregnant women with normal glucose tolerance (NGT, n=45) consecutively and fasting non-pregnant healthy women (n=45). Blood samples were obtained in the third trimester in both pregnant groups. The blood samples were analyzed for plasma and intracellular zinc by Flame Atomic Absorption Spectrophotometry (FAAS). Results: Plasma zinc level in normal pregnant, compared to non-pregnant controls were (11.40±2.51 µmol/l vs 15.55±2.48 µmol/l, p?0.0001; zinc in erythrocytes 0.65±0.12 ?mol/l/g Hb vs 0.56±0.09 ?mol/l/g Hb, p?0.0001) and GDM women, compared to non-pregnant controls (11.81 ± 2.42 µmol/l vs.15.55±2.48 µmol/l, p?0.0001; zinc in erythrocytes 0.66±0.13?mol/l/g Hb vs. 0.56±0.09 ?mol/l/g Hb, p?0.0002). The study founded positive correlation between plasma zinc levels and pro-insulin in GDM pregnant (r=0.225) and expected negative in healthy pregnant women (r=-0.119). Conclusion: The survey did not identify statistically significant differences between healthy pregnant women and those with GDM in the level of plasma and hemolysate zinc. Both pregnant groups had higher level of intracellular erythrocyte zinc in comparison to non-pregnant.


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[Mariana P.Genova, Bisera Atanasova, Katia Todorova-Ananieva and Kamen Tzatchev (2014); PLASMA AND INTRACELLULAR ERYTHROCYTE ZINC LEVELS DURING PREGNANCY IN BULGARIAN FEMALES WITH AND WITHOUT GESTATIONAL DIABETES Int. J. of Adv. Res. 2 (6). 0] (ISSN 2320-5407). www.journalijar.com


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