01Jan 2017

Prevalence of C. difficile in patients with antibiotic associated diarrhea in a tertiary care hospital.

Abstract


Context: C. difficile is a major cause of hospital acquired diarrhea. Aims: A prospective study was carried out to determine the prevalence of C. difficile in patients with antibiotic associated diarrhea (AAD) in a tertiary care hospital. Methods and Material: 162 stool samples were examined over a two year period for toxin A and toxin B via C. difficile Toxin A+B Stool Antigen Microwell ELISA kit (IVD Research Inc.). Clinical and demographic data was collected from all patients. Results: The prevalence of C. difficile associated diarrhea was found to be 4.32%. Highest number of C. difficile toxin positive cases was from stool samples of patients admitted in oncology/ hematology followed by internal medicine. Median time of occurrence of symptoms was 7 days after admittance to hospital. All the patients were on multiple antibiotics. Conclusion: This present prospective study draws attention to the role of C. difficile as a cause of AAD in our hospital. Active and aggressive surveillance and sampling before putting patients empirically on anti- C. difficile treatment will determine the true prevalence of C. difficile in our hospital. Timely laboratory results of C. difficile testing can impact decisions regarding antibiotic therapy and infection control measures.


Cite This Article as:


[Gulnaz Bashir, Danish Zahoor, Mushtaq Ahmad Khan, Dalip Kumar Kakru, TehmeenaWani, Bashir Ahmad Fomda (2014); Prevalence of C. difficile in patients with antibiotic associated diarrhea in a tertiary care hospital. Int. J. of Adv. Res. 2 (6). 0] (ISSN 2320-5407). www.journalijar.com


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