STUDY OF COMPARISON OF LIVER FUNCTION TESTS IN DIABETES CASES AND NON-DIABETICS CONTROLS.

Introduction: diabetes is a metabolic disorder characterized by increased levels of blood glucose due to impairment in insulin action and/or insulin secretion. Liver plays a major role in the regulation of carbohydrate metabolism. It uses glucose as a fuel, store glucose as glycogen; also synthesize glucose from non-carbohydrate sources. Therefore, liver is more susceptible to diseases. Materials and methods: the study comprises of 100 subjects, out of whom 50 were diabetic cases and 50 non-diabetic control subjects. The subjects were those attending outdoor and indoor in New Medical College Hospital Kota, Rajasthan, India. Liver function test estimation by various methods mentioned above on fully automatic analyzer.Quantitative data was summarized in the form of mean ? sd and differences in means of both the groups were analyzed by unpaired student?t? test using graph pad prism.P-value less than 0.05 were considered significant. Results: the mean activity of serum bilirubin total (1.74 ? 0.897), bilirubin direct (0.474 ? 0.264), serum ast (62.56 ? 39.84 iu/l), serum alt (49.38 ? 45.85 u/l) and serum alp (134.32 ? 67.7 iu/l) of diabetic patients shows significant difference from that of normal subjects. Conclusion: the outcome of the present study shows that liver enzymes have higher activity in dm patients than controls. Thus screening for liver dysfunction in diabetics and subsequent workup may lead to early detection of hepatic co-morbidities and better management.