13May 2018

THE EFFECT OF PREGABALIN VERSUS CARBAMAZEPINE ON THE GINGIVA OF ALBINO RATS WITH THE POSSIBLE MODULATORY ACTION OF ACASIA ARABICA.

  • B.D.S. 6 October University (2004) MSC. Oral Biology, Cairo University (2012), Assistant Lecturer of Oral Biology, Faculty of Dentistry, MSA University.
  • Professor and Head of Oral Biology department, Faculty of Dentistry, Ain Shams University.
  • Professor of Oral Biology, Faculty of Dentistry, Badr University in Cairo.
  • Lecturer of Oral Biology, Faculty of Dentistry, Ain Shams University.
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Aim: The aim of this study was to compare the effect of anticonvulsant Pregabalin versus Carbamazepine, with and without Acacia Arabica on the rats' gingiva. Materials and methods: 35 adult male albino rats were divided into: control group contained seven rats received distilled water for three weeks, experimental group I contained seven rats received Carbamazepine (20 mg/kg), subgroup I contained seven rats which received Carbamazepine (20 mg/kg) and Acasia Arabica (100 mg/kg), group II contained seven rats received Pregabaline (20 mg/kg) and subgroup II contained seven rats received Pregabaline (20 mg/kg) and Acasia Arabica (100 mg/kg). After three weeks, all rats were terminated and the mandibular molar regions were excised, fixed then decalcified and stained with H & E. The epithelium thickness was measured using morphometric analysis and the gingival specimens were examined for the expression of Ki-67 antigen. Results: The side effects on the gingiva either histologically or immuno histochemically were severe with Carbamazepine and mild with Pregabalin. Results also showed a great modulating effect of Acacia Arabica on the enlarged gingiva. Conclusion: Pregabalin treatment has milder deletarious effects on the gingiva when compared with Carbamazepine.

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[Ahmed Osama Hafiz Mohamed, Ahmed Mahmoud Halawa, Rania Mossad Hassan and Marwa Mohamed Abd El-Hameed. (2018); THE EFFECT OF PREGABALIN VERSUS CARBAMAZEPINE ON THE GINGIVA OF ALBINO RATS WITH THE POSSIBLE MODULATORY ACTION OF ACASIA ARABICA. Int. J. of Adv. Res. 6 (May). 158-165] (ISSN 2320-5407). www.journalijar.com

Ahmed Osama Hafez
Assistant Lecturer of Oral Biology, Faculty of Dentistry, MSA University

DOI:

Article DOI: 10.21474/IJAR01/7019      
DOI URL: http://dx.doi.org/10.21474/IJAR01/7019

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