10Jul 2018

AQUEOUS EXTRACT OF INDIAN COSTUS ROOTS EFFECTS ON A DIET-INDUCED HYPERCHOLESTEROLEMIA IN MURINE MODEL.

  • Department of Pharmacology-Faculty of Vetrinary Medicine-Omar Al-mukhtar University-Albeida-Libya.
  • Department of Pathology- Faculty of Vetrinary Medicine- Omar Al-mukhtar University-Albeida-Libya.
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The present study was designed to investigate the effects of aqueous extract of Indian costus roots on lipid profile in a diet-hypercholesterolemic mice. The subjects were randomized into 3 groups: Group A (Normal Control); Group B ( Hypercholesterolemic Control); Group C (Hypercholesterolemic + Indian costus treated). Hyperlipidemia was induced by feeding high fat diet. After 3 weeks of hypercholesterolemic diet , body weights, blood cholesterol level, triglycerides , Plasma enzyme ALT, AST and ALP levels were measured. The oral administration of aqueous extract of Indian costus roots shows reduction in total cholesterol, triglycerides and Plasma enzyme ALT, AST and ALP levels in hypercholesterolemic mic compared to normal group. The findings of this study indicated that the administration of Indian costus improved level of lipid profile and decreased in the Plasma enzyme ALT, AST and ALP levels in hypercholesterolemic mice.


  1. Akhtar F M, Ali M R (1984) : Study of the antidiabetic effect of a compound medicinalplant prescription in normal and diabetic rabbit, Journal of Pakistan Medical Association, 34: 239-244.
  2. Anderson J W (2003) : Diet first, then medication for hypercholesterolemia, JAMA , 290: 531-34.
  3. Bavarva J H and Narasimhacharya A V (2008) : Antihyperglycemic and hypolipidemic effects of
  4. Costus speciosus in alloxan induced diabetic rats, Journal of Phytotherapy Research , 22(5): 620-626.
  5. Buyssens N, Kockx M M, Herman AG, Lazou J, Van den Berg K, Wisse E, and Geerts A (1996): Centrolobular liver fibrosis in the hypercholesterolemic rabbit, Journal of Hepatology , 24(4): 939-946.
  6. Colca, J.R (2006): Insulin sensitizer may prevent metabolic inflammation. Biochem.Pharmacol, 72, 125-131.
  7. Daisy P, Eliza J? and? Ignacimuthu S (2008) : Influence of Costus speciosus (Koen.) Sm. Rhizome extracts on biochemical parameters in streptozotocin induced diabetic rats, Journal of Health Science, 54(6): 675-681.
  8. Del Moral M L, Esteban FJ, Torres M I, Camacho M V, Hernandez R, Jimenez A, Aranega A, Pedrosa J A and Peinado M A (1997): High-fat sunflower and olive oil diets affect serum lipid levels in steatotie rat liver differently. Journal of? Science. Vitaminol, 43: 155-160.
  9. Duraipandiyan V, Al-Harbi N A, Ignacimuthu? S and? Muthukumar C (2012) : Antimicrobial activity of
  10. sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen) Sm. BMC Complementary and Alternative Medicine, 12(13): 2-6.
  11. Eliza J, Daisy P, Ignacimuthu S, Duraipandiyan V (2009) : Normo-glycemic and hypolipidemic effect of costunolide isolated from Costusspeciosus (Koen.)Sm. in streptozotocin-induced diabetic rat, Journal of Chemico-Biological Interactions, 179: 329?334
  12. El-khishin I A and Amer M G (2010) : Possible protective role of l-carnitine on diclofenac induced hepatotoxicity in adult male albino rats , Histological, Immunohistochemical
  13. and Biochemical Study. Journal of Histolgy, 33(2): 341-352.
  14. Hansel R, Keller K, Rimpler H and Schneider G (1994) :? Hagers Handbuch der Pharmazeutischen Praxis. 5. Auflage., Bde 4 ? 6 .Drogen, Springer Verlag Berlin, Heidelberg, New York.
  15. Keskin E, Uluisik D, Altin M (2015) : Effects of l-carnitine on liver enzymes in rats fed cholesterol rich diet,
  16. Journal of Animal and Veterinary Sciences, 3(4): 117-119.
  17. Lin Y, Meijer G W, Vermeer M A, Trautwein E A (2004) : Soy protein enhances the cholesterol lowering effect of plant sterol ester in cholesterol-fed hamsters. Journal of Nutur , 134: 143-48
  18. Mhamed M, Naoufel A Z, Jean-Baptiste M and Mohamed E (2005) : Antihypertensive effect of Lepidium sativum in spontaneously hypertensive rats, Journal of Ethnopharmacology, 100: 193?197
  19. Mogill P C and Mott O L (1976) :? Diet and Cornoary heart disease, Jornal of Nutur. Rev, 3: 202-204
  20. Nanji A A, Rahemtulla A, Daly T, Khwaja S, Miao L, Zhao S and Tahan S R (1997) : Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat, Journal of Hepatology, 26(1): 90-97.
  21. Nehete J, Bhatia Mand Narkhede M (2010):In-vitro Evaluation of Antioxidant Activity and Phenolic Content of Costus speciosus (Koen) J.E. Sm,Iranian Journal of Pharmaceutical Research, 9 (3): 271-277
  22. Pandey M, Rastogi S, Rawat? A (2007) :? Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant. Journal of Ethnopharmacology, 110: 379-390.
  23. Rajesh M S, Harish M S, Sathyaprakash R J, Shetty A R, Shivananda T N: Antihyperglycemic activity of the various extracts of Costus speciosus rhizomes, Journal of Natural Remedies, 9(2): 235-241.
  24. Renugadevi J and Prabu S M (2010) :? Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp. Toxicol. Pathol, 62(2): 171-181.
  25. Revathy J, Sheik Abdullah S,? Sampath Kumar P (2014) : ntidiabetic Effect of Costus Speciosus rhizome extract in alloxan induced albino rats, Journal of Chemistry and Biochemistry, 2: No. 1.
  26. Robinson A, Kumar T V, Sreedhar E, Naidu VG, Krishna S R, Babu K S, Srinivas P V, Rao J M (2008) : A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study, Jornal of Med. Chem. Lett, (14): 4015-4017.
  27. Shew W H, Jeng? C Y, Lee? W J, Lin S Y, Pei D, Chen Y T (2001) : Simvastatin treatment in postprandial hypertriglyceridemia in type 2 diabetes mellitus patients with combined hyperlipidemia, Journal of? Metabol , 50: 355-359.
  28. Yadav Y C, Srivastav D N, Seth A K, Gupta V D and Kuldeep S (2009) : Nephroprotective and curative activity of Lepidium Sativum L. seeds in albino rats using cisplatin induced nephrotoxicity. Journal of Pharmacology on line,3: 640-646.

[Kaula Ahmed Saad, Hanan Ali Alkailani, Najah Abdulrahim Mohamad, Suad Abdulhadi Saeed and Fawzia Abdalla Mohamed. (2018); AQUEOUS EXTRACT OF INDIAN COSTUS ROOTS EFFECTS ON A DIET-INDUCED HYPERCHOLESTEROLEMIA IN MURINE MODEL. Int. J. of Adv. Res. 6 (Jul). 25-29] (ISSN 2320-5407). www.journalijar.com


Kaula Ahmed Saad
Department of Pharmacology-Faculty of vetrinary medicine-Omar Al-mukhtar University-Albeida-Libya.

DOI:


Article DOI: 10.21474/IJAR01/7331      
DOI URL: http://dx.doi.org/10.21474/IJAR01/7331