Resistin as an Early Diagnostic Marker for Identification of Neonatal Sepsis in Comparison With C-reactive Protein
Abstract: Background: The study was designed to evaluate the diagnostic value of resistin in neonatal sepsis, and to compare these adipocytokine with C-reactive protein (CRP). Neonates were recruited from neonatal intensive care unit (NICU) of Ain Shams University in the period from January 2012 till September 2012. This study included 90 neonates, group1 (proved sepsis) 30 neonates were diagnosed to have neonatal sepsis clinically and laboratory [18 males (60%) and 12 females (40%)], Group2 (suspected sepsis) 30 neonates were suspected to have neonatal sepsis clinically but laboratory free [13 males (43.3%) and 17 females (56.7%)] and control group (group3) of 30 health neonates [16 males (53.3%) and 14 females (46.7%)]. Methods: All patients in the study were subjected to history taking, full clinical examination, CBC, CRP, blood culture and serum Resistin assay at the time of diagnosis of sepsis by enzyme linked immunosorbant assay (ELISA). Results: That neonates with neonatal sepsis had their serum resistin levels significantly higher than those of the control group, as mean serum resistin level was (38.5±7.3 ng/ml), (23.9±8.5 ng/ml), and (7.2±2.6 ng/ml) in group 1, 2 and 3 respectively. Our study found that serum resistin is of diagnostic value in early onset neonatal sepsis (p<0.01) and it had superior efficacy to CRP i.e the best cut off level was 17.5 ng/ml and 12.5 ng/ml for sepsis and suspected sepsis respectively. Conclusion: Resistin is of diagnostic value in early onset neonatal sepsis as serum resistin values were significantly higher in septic neonates compared to healthy controls with positive correlation with CRP in cases.
[Abousaif, N M ABU-SHADY, N Refaat, Sh Abdel Moneam (2014); Resistin as an Early Diagnostic Marker for Identification of Neonatal Sepsis in Comparison With C-reactive Protein Int. J. of Adv. Res. 2 (8). 0] (ISSN 2320-5407). www.journalijar.com
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