Phytochemical screening and evaluation of antihyperglycemic and antihyperlipidimic activity of methanolic extracts of calophyllum inophyllum on Albino Wistar Rats

Calophyllum inophyllum L. has been used as folk medicine in the treatment of ocular burn and it has demonstrated potential to be an anti-diabetic agent. The aim of the study is to perform preliminary phytochemical screening, and to evaluate and compare the anti-inflammatory effect of methanolic extracts of leaf and stem bark of Calophyllum inophyllum. Calophyllum inophyllum leaves and stem bark were extracted using methanol as solvent by Soxhlet apparatus. The percentage yield of CILE was found to be 16.27% and percentage yield of CISBE was found to be 17.62%. Preliminary phytochemical screening revealed the presence of alkaloids, carbohydrates, glycosides, saponins, tannins, flavonoids, proteins, amino acids and steroids. Doses up to 2000mg/kg were found to be safe after acute toxicity tests. The results for alloxan induced diabetes in albino wistar rats depicted significant antihperglycemic and antihyperlipidimic activity .