RELATIONSHIP OF HEAVY METAL IN DIABETES AND NON-DIABETIC FOOT ULCER PATIENTS.
- KPC Medical College & Hospital, Kolkata.
- Ramakrishna Mission SevaPratishthan, Kolkata.
- Institute of Post-Graduate Medical Education and Research, A.J.C. Bose Road, Kolkata-700020, West Bengal, India.
- Cite This Article as
- Corresponding Author
Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. The aim of our study was to find out any relationship of heavy metals like Arsenic, Cadmium, Mercury, Lead, Chromium, Barium, Cobalt, Caesium We found that mean arsenic of Type2 DM with Foot Ulcer patients had significantly higher than others. Mean cadmium level had significantly lower in Type2 DM with Foot Ulcer than Healthy Control (t=3.5689). It may conclude that mercury level had lower in diabetic patients. Mean lead level had significantly higher in Type2 DM with Foot Ulcer than Healthy Control (t=2.3510). T-test showed that mean lead of Type2 DM with Foot Ulcer patients had significantly higher than others. Mean chromium level had significantly higher in Type2 DM with Foot Ulcer than others but that was not statistically significant. T-test showed that mean barium of Type2 DM without foot ulcer patients had significantly higher than others. Mean cobalt, caesium and selenium level had significantly higher in Type2 DM with Foot Ulcer than others but that was not statistically significant. It can be suggested that toxic metals such as arsenic, cadmium, mercury, lead, chromium, barium, cobalt, caesium and selenium may have a role to induce foot ulcer in diabetic subjects.
- Nomikos IN, Malizos C, Vamvakopoulos NC. Protective and damaging aspects of healing: a review. WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE. 2006 Jul 1;18(7):177-85.
- Balaji, S.; Han, N.; Moles, C.; Shaaban, A.F.; Bollyky, P.L.; Crombleholme, T.M.; Keswani, S.G. Angiopoietin-1 improves endothelial progenitor cell-dependent neovascularization in diabetic wounds. Surgery 2015, 158,846?856.
- Yazdanpanah L, Nasiri M, Adarvishi S. Literature review on the management of diabetic foot ulcer. World journal of diabetes. 2015 Feb 15;6(1):37.
- Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. The Journal of clinical investigation. 2007 May 1;117(5):1219-22.
- Turns M. Diabetic foot ulcer management: the podiatrist\'s perspective. British journal of community nursing. 2013 Dec 1;18(Sup12):S14-9.
- Reiber GE, Boyko EJ, Smith DG. Lower extremity foot ulcers and amputations in diabetes.Diabetes in America. 1995 Jul 1;2:40927.
- Stockl K, Vanderplas A, Tafesse E, Chang E. Costs of lower-extremity ulcers among patients with diabetes. Diabetes Care. 2004 Sep 1;27(9):2129-34.
- Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: 6.global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pr. 2013;94(3):311-21
- Viswanathan V, Thomas N, Tandon N, Asirvatham A, Rajasekar S. Profile of diabetic foot complications and its associated complications-a multicentric study from India. JAPI. 2005 Nov 7;53:933-6.
- Ghisleni MM, Biolchi V, Jordon BC, et al. Association study of C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene with diabetes mellitus type 2 and distal diabetic polyneuropathy. Mol Med Rep 2015;12:4626?33.
- Simsek A, Aykut O. Evaluation of the microelement profile of turkish hazelnut (corylusavellana L.) varieties for human nutrition and health. Int J Food SciNutr. 2007;58(8):677?688..
- Soetan KO, Olaiya CO, Oyewole OE. The importance of mineral elements for humans, domestic animals and plants: a review. Afr J Food Sci. 2010;4(5):220?222.
- Grivetti L. Value of traditional foods in meeting of macro- and micronutrients needs: the wild plants connection. Nutr Res Rev. 2000;13:31?46.
- Fraga CG. Relevance, essentiality and toxicity of trace elements in human health.Mol Aspects Med. 2005;26(4?5):235?244.
- McCall KA, Huang C, Fierke CA. Function and mechanism of zinc metalloenzymes. J Nutr. 2000;130(5S Suppl):1437S?1446S.
- Lu Y, Yeung N, Sieracki N, Marshall NM. Design of functional metalloproteins.Nature. 2009;460(7257):855?862.
- Lutsenko S, Barnes NL, Bartee MY, Dmitriev OY. Function and regulation of human copper-transporting ATPases.Physiol Rev. 2007;87(3):1011?1046.
- Guidotti T, McNamara J, Moses M. The interpretation of trace element analysis in body fluids. Indian J Med Res. 2010;128(4):524.
- Chen YW. Heavy metals, islet function and diabetes development. Islets. 2009;1(3):169?176. doi: 10.4161/isl.1.3.9262.
- Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem. 2005;12(10):1161?1208.
[Prasanta Kumar Bhattacharyya,Priyanka Biswas, Debarshi Jana, Jayanta Ranjan Mukherjee and Madhusanta De. (2019); RELATIONSHIP OF HEAVY METAL IN DIABETES AND NON-DIABETIC FOOT ULCER PATIENTS. Int. J. of Adv. Res. 7 (3). 126-133] (ISSN 2320-5407). www.journalijar.com
Institute of Post-Graduate Medical Education and Research, A.J.C. Bose Road, Kolkata-700020, West Bengal, India
Article DOI: 10.21474/IJAR01/8610 DOI URL: http://dx.doi.org/10.21474/IJAR01/8610
Share this article
This work is licensed under a Creative Commons Attribution 4.0 International License.