The relationship between Matrix Metalloproteinase-10 (MMP-10) and atherosclerosis in Patients with chronic kidney disease

Background: Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD). Aim: As matrix metalloproteinases have a major role in atherosclerosis, we investigated the relationship between matrix metalloproteinase (MMP-10) and the severity of atherosclerosis in patients with chronic kidney disease. Methods: This study was evaluated in a cross-sectional study of 40 patients of CKD subdivided into 20 patients with different stages of kidney disease and 20patients on dialysis and 20 healthy controls. The severity of atherosclerosis was estimated with carotid intima media thickness (CIMT) by carotid ultrasound. Serum level of (MMP-10) was measured by ELISA. Results: MMP-10 level in the control group was ranging between 346 and 776 pg/dl with a mean of (601 + 132.12) and in the earlier stages of CKD group was ranging between 989 and 2569 pg/dl with a mean of (1857.45+ 387. 1). Also MMP-10 in patients on dialysis group (HDx) group was ranging between 1790 and 2986 pg/dl with a mean of (2306.45 + 335.247). The difference between all groups was statistically significant with P value <0.001. The carotid intima media thickness (CIMT) between all groups was statistically significant with P- value <0.001 between the HDx group and other groups and P value= 0.045 between the control and the CKD group. Also there was statistically significant positive correlation between MMP-10 and CIMT in all groups. Conclusion: MMP-10 was significantly increased in patients with kidney disease compared with the healthy controls, and was higher in patients on dialysis than in earlier stages of CKD. The severity of the atherosclerosis was also more prevalent in the dialysis group, in which serum levels of MMP-10 was significantly higher. Thus, patients with CKD exhibit elevated levels of circulating MMP-10, and this was independently associated with the severity of atherosclerosis and may represent a new biomarker of atherosclerotic diseases.