A Genomic Study Of Egyptian Type 2 Diabetics Attending The Outpatient Clinic Of National Institute of Diabetes and Endocrinology.

Aims: A panel of single nucleotide polymorphisms (SNPs) in patients with type 2 diabetes mellitus (T2DM) is being evaluated compared to a non diabetic population. This study was designed to study the most common SNPs associated with type 2 diabetes to identify genetic markers in Egyptian type 2 diabetics. Main Methods: 71 subjects were subdivided: Group I: included 49 type 2 diabetic subjects, Group II: included 22 normal subjects. The following SNPs genotypes were studied: (rs10010131, rs7754840 , rs1470579, rs13266634 and rs10923931). Key Findings: The IGF2BP2 rs1470579 polymorphism showed the highest odds ratio (OR) for type 2 diabetes group (4.714). Odds ratio of other polymorphisms ranged from 1.131 to 4.270. The logistic regression used to assess the contribution of individual SNPs to risk of type 2 diabetes showed that the IGF2BP2 rs1470579 polymorphism showed significant risk of type 2 diabetes, The other polymorphisms are showed insignificant risk of type 2 diabetes. Significance: The SNPs (IGF2BP2 rs1470579) was found to be associated with an enhanced risk of future diabetes and prediction of future disease in Egyptian diabetic patients. This finding can be used in the prediction, prevention and early detection of the disease especially if the study is applied to large scale.