01Aug 2019

INVOLVEMENT OF SCHISTOSOMA HAEMATOBIUM IN HEPATIC INJURY IN PAPA VILLAGE, SOUTHWEST NIGERIA.

  • William Newton Memorial Hospital, Winfield, Kansas 67156 USA.
  • Coffey County Hospital Laboratory, Burlington, Kansas 66839 USA.
  • Department of biomedical sciences, Ladoke Akintola University of technology, Ogbomosho,Nigeria.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Neglected tropical disease such as urinary schistosomiasis have had devastating effects on the renal system, which has been extensively studied but its effect on the liver and liver proteins still remain largely unknown despite schistosoma haematobium spending a major part of its lifecycle in the veins surrounding the liver and hepatic portal system. In this experiment, we assessed the prevalence and effect of schistosoma haematobium on the human liver among the dwellers of Papa village, Osun state Nigeria. We utilize 60 test samples consisting mainly of the dwellers from Papa village and 60 control samples collected from Osogbo urban city in Osun state Nigeria, which were screened for schistosoma haematobium eggs to establish prevalence of the parasite. Also, both the test sample and control sample were subjected to coagulation and biochemical analysis to ascertain the severity of schistosoma haematobium on the liver. The result showed the presence of an average of 440 eggs of schistosoma haematobium per 10 mls in the test population and no schistosoma haematobium egg in the control population. There was a significant difference in the value of total protein, globulin, albumin, erythrocyte sedimentation rate, prothrombin time and partial thromboplastin time with kaolin when the test population was compared to the control population. These blood parameters were indicative of the severity of schistosoma haematobium infection on the liver. Combination strategies such as Intensive health education, vector control and early treatment should be recommended in combating the presence of schistosoma haematobium and prevent egg migration in visceral organs of the body, including the liver.


  1. Anigbo, E. U. and Nwaorgu, O. C. (1994). Urinary Schistosomiasis in two family populations, using school children as tracer. Nig. J. Parasitol., 9(11): 41-46.
  2. Anto, F., Asoala, V., Adjuik, M. A., Anyorigiya, T., Oduro, A. R., Akazili, J., Akweongo, P., Ayivor, P. K., Bimi, L. and Hodgson, A. V. O. (2013). Water Contact Activities and Prevalence of Schistosomiasis Infection among School-age Children in Communities along an Irrigation Scheme in Rural Northern Ghana. J. Bacteriol. Parasitol., 4: 177.
  3. Badmos, K. B.,?Komolafe, A. O.?and Rotimi, O. (2007). Schistosomiasis presenting as acute appendicitis. East Afr. Med. J., 83: 528-532.
  4. Chitsulo, L., Engels, D., Montresur, A. and Saviol,i L. (2000). The global status of schistosomiasis and its control. Acta Trop., 77: 41-51.
  5. Cowper, S. G. (1963). Schistosomiasis in Nigeria. Trop. Med. Parasitol., 57:307-332.
  6. DeWitt,?W. B. and Warren, K. S. (1959). Hepato-Splenic Schistosomiasis in Mice. ?Am. J. Trop. Med. Hyg., 8(4): 440 ? 446.
  7. Elagba, H. A., Mohamed, E. and Hikmat, I. (2006). Haematological and Biochemical morbidity of Schistosoma Haematobium in school children in Sudan. Sultan Qaboos Univ. Med. J., 6(2): 59-64.
  8. Gray, D. J., Ross, A. G., Li, Y. and McManus, D. P. (2011). Diagnosis and management of schistosomiasis. Br. Med. J., 342:d2651.
  9. Groeneveld, A. E., Marszalek, W. W. and Heyns, C. F. (1996). Bladder cancer in various population groups in the greater Durban area of KwaZulu-Natal: South Africa. Br. J. Urol., 78:205-8.
  10. Gryseels, B. and DeVlas, S. J. (1996). Worm burdens in schistosome infections. Parasitology Today, 12:115-119.
  11. Gryseels, B. and Nkulikyinka, L. (1988). The distribution of Schistosoma mansoni in the Rusizi plain (Burundi). Ann. Trop. Med. Parasitol., 82: 581-590.
  12. Gryseels, B.,?Polman, K.,?Clerinx, J. and?Kestens, L. (2006). Human schistosomiasis. Lancet,?368:?1106-1118.
  13. Ismail, K., Ahmed, S. and Mohamed, S. (2013). Urologic complications of genitourinary schistosomiasis. World J. Urol., 30(1): 31?8.
  14. McManus, D. P. and Loukas, A. (2008). Current status of vaccines for schistosomiasis. Clin. Microbiol. Rev., 21: 225-242.
  15. McPherson, R. A. (1984). Specific proteins. In: Clinical diagnosis and management, Henry, J. B. ed. Philadelphia: W. B. Saunders, 204-14.
  16. Mebius, M. M., van Genderen, P. J. J., Urbanus, R. T., Tielens, A. G. M., de Groot, P. G., van Hellemond, J. J. (2013). Interference with the Host Haemostatic System by Schistosomes. PLoS Pathog., 9: 12 e1003781.
  17. Mott, K. E., Desjeux, P. and Moncayo, A. (1990). Parasitic diseases and urban development. Bull. World Health Organ., 68(6): 691-698.
  18. Oyinloye, B., Adenowo, F., Gxaba, N. and Kappo, A. (2014). The promise of antimicrobial peptides for treatment of human schistosomiasis. Curr. Drug Targets, 15: 852-9.
  19. Smith, J. H. and Christie, J. D. (1986). The pathobiology of?schistosoma haematobiuminfection in humans. Hum. Pathol., 17(4): 333-345.
  20. Steinmann, P.,?Keiser, J., Bos, R.,?Tanner, M. and?Utzinger, J. (2006). Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Dis.,?6: 411-425.
  21. Vennervald, B. J. (2015) Epidemiology and Mechanism of Carcinogenesis of Schistosomiasis. In: Droz, J. P., Carme, B., Couppi?, P., Nacher, M. and Thi?blemont, C. (eds) Tropical Hemato-Oncology. Springer, Cham.
  22. WHO Schistosomiasis fact sheets (2016) viewed at www.who.int/mediacentre/factsheets/fs115/en/. Accessed 05.05.19.
  23. WHO schistosomiasis fact sheet. (2014). http:// who.int/mediacentre/factsheets. accessed 05.05.19.
  24. Zaghloul, M. S. (2012). Bladder cancer and schistosomiasis. Egypt. Natl. Canc. Inst., 24: 151-159.
?

[Oladapo A. A., Ogundiran S. M and Oseni B. S. A. (2019); INVOLVEMENT OF SCHISTOSOMA HAEMATOBIUM IN HEPATIC INJURY IN PAPA VILLAGE, SOUTHWEST NIGERIA. Int. J. of Adv. Res. 7 (Aug). 130-138] (ISSN 2320-5407). www.journalijar.com


AA Oladapo
William Newton Memorial Hospital, Winfield, Kansas 67156 USA.

DOI:


Article DOI: 10.21474/IJAR01/9485      
DOI URL: http://dx.doi.org/10.21474/IJAR01/9485