02Oct 2019

OPTIMIZATION OF POLYMER TOUGHENING PROCESS OF SOLID HYDROXYAPATITE IMPLANT.

  • Faculty of Engineering, Gharyan University, Ministry of Education ? Libya.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

The experimental work of this study was conducted using a statistical experimental design in conjunction with the Taguchi method for optimization. The most effective factors affecting the toughening of the ceramic pellets were evaluated. The target of this experimental work was to maximize the product strength and minimize the amount of deposited polymer on the product. The Taguchi signal-to-noise (S/N) ratio was used for the optimization process. The experiments were divided into three stages. Stage One was identifying the parameters and the determination of the range of values to be explored; this step is usually done through literature review and simple experiments. Stage Two was the screening experiments (process characterization) to find out the most significant parameters effects on the process; this stage is done through the design of an orthogonal array based on the number of the input factors into the process. Stage Three was the optimization process itself [1-10]. Stages One and Two were reported in a previous study [9]. Stage Three is the subject of this study; for this stage the levels of the candidate factors were narrowed for more precise optimization. Four candidate factors with three levels were tried using an L9 (34) orthogonal array. The results were optimized using a statistical experimental design using the analysis of means and orthogonal array. The excess polymer removal technique used and the number of polymer solution coatings showed major effects on the flexural strength. Presumably, because these affect the mass of polymer applied. Optimum values of the flexural strength and mass of polymer were determined using statistical experimental design and the Taguchi method. Using the optimum experimental condition for preparing samples produces high quality in dense implants with 10.49 MPa flexural strength and 80 μm thickness of the deposited polymer, with mass of 21.0 mg / sample.


  1. JohnsonL., Leone F.C., Statistics and Experimental Design, John Wiley & Sons, 1977,12 ? 30.
  2. Barker T. B., Quality Engineering by Design: "Taguchi's Philosophy", Quality Progress, Vol.19/12 1986.
  3. Saeed Maghsoodloo, Guttekin Ozdemir, Victoria Jordan, Chen-HsiuHuang, ?Strengths and limitations of Taguchi?s contributions to quality, manufacturing, and process engineering?, Journal of Manufacturing Systems, Volume 23/ 2, 2004, 73-126.
  4. Nataraj, V.P. Arunachalam, G. Ranganathan, ?Using risk analysis and Taguchi?s method to find optimal conditions of design parameters: a case study?, The International Journal of Advanced Manufacturing Technology, 2006,?V 27/5?6,? 445?454
  5. Byrne D.M. and Taguchi G., "The Taguchi approach to parameter design", American Society for Quality Congress, Anaheim, 1986.
  6. Han-Xiong Li, XinJiang Lu, System Design and Control Integration for Advanced Manufacturing, J.wiley, 2014, 370?376
  7. Taguchi G., System of experimental design, Vol. 1, edited by D. Clausing, UNIPUB/Kraus international publications, New York, 1987.
  8. Vinitkumar K. Modi, Darshak A. Desai, Review of Taguchi Methodology, 2018, V5/1, JETIR (ISSN-2349-5162).
  9. Ajaal Tawfik, D. thesis, Queen?s University, Kingston, Ontario, Canada, 2002.
  10. Reginald W. Smith & Tawfik T. Ajaal, Technical Report, Development of skeletal composites of synthetic bone mineral and biodegradable polymers, submitted to Millennium Biologix Inc. (MBI), 2002.
  11. Khan SN, Bostrom MPG, Lane JM, Tissue engineering in orthopedic surgery; bone growth factors, Orthopedic Clinics of North America, volume 31, number 3, 2000, 1 ? 16.
  12. Anant Mahapatra, and Wasim S Khan,Tissue Engineering in Orthopaedics and Musculoskeletal Sciences, Open Orthop J.5, 2011, 239 ?241.
  13. Flahiff CM, Blackwell AS, Hollis JM, Feldman DS, Analysis of biodegradable composite for bone healing, J Biomed Mater Res 31,1996, 419 ? 414.
  14. Zeeshan Sheikh, Shariq Najeeb, Zohaib Khurshid, Vivek Verma, Haroon Rashid and Michael Glogauer, Biodegradable Materials for Bone Repair and Tissue Engineering Applications, Materials 2015, 8, 5744-5794
  15. Hollinger J, Battistone G., Biodegradable bone repair materials. Synthetic polymers and ceramics, Clin Orthop 1986, 207:290 ? 305.
  16. XIAOHUA LIU and PETER X. MA, Polymeric Scaffolds for Bone Tissue Engineering, Annals of Biomedical Engineering, Vol. 32/3, 2004, 477?486.
  17. Casaletto MP, Kciulis S, Mattogno G, Mezzi A, Ambrosio L, Branda F, XPS characterization of biocompatible hydroxyapatite-polymer coatings, Surface and Interface Analysis 34/1, 2002, 45 ? 49.
  18. Langstaff S, et al.., Resorbable bioceramics based on stabilized calcium phosphates, Part II: Evaluation of biological response, Biomaterials 22 ,2001, 135 ? 150.
  19. Williams DF., Biodegradation of surgical polymers, J Mater Sci; 17, 1982, 1233 ?1246.
  20. Prashant M. Satturwar, Suniket V. Fulzele, and Avinash K. Dorle, Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer, AAPS Pharm SciTech. 2003, 434?439
  21. Bostman OM. Current concepts review. Absorbable implants for fixation of fractures. J Bone Jt Surg (Am) 1991,73: 148 ? 153.
  22. Sushil Rangdal, Kanniraj M, Narendra Joshi, Rakesh Bhargava, Daljit Singh, Critical Evaluation Of Biodegradable Implants In Intraarticular Fracture Fixation: A Recent Experience In India, J. Orthopaedics2010, 7(4)e7
  23. Williams DF., Mechanisms of biodegradation of implantable polymers. Clin Mater 1992; 10: 9 ? 12.
  24. Hansoo ParkJohnna S. TemenoffAntonios G. Mikos, Biodegradable Orthopedic Implants, Engineering of Functional Skeletal Tissues, Springer, London, 2007,55-68
  25. Daniels AV, Chang MKO, Andias KP, Heller J, Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone, J Appl Biomater 1, 1990, 57 ? 78.
  26. Gupta N, Kishore E, Bet W, Sankaran S, Studies on compressive failure features in synthetic foam material, J Mater Sci 36, 2002, 4485 ? 4491.
  27. Eyassu Woldensenbet, Narendra Sankella, Flexural Properties of Nanoclay Syntactic Foam Sandwich Structures, Journal of Sandwich Structures & Materials, V.: 11 / 5: 5, 2009, 425-444
  28. Amjad Z, editor. Calcium phosphates in biological and industrial systems. Boston, MA: Kluwer Academic Publishers, 1997, 529 - 539.
  29. Sharon Kehoe, Calcium Phosphates for Medical Applications, Editor: Joseph T. Stokes Publishers: Dublin City University, 2008
  30. Park JB, Bronzino JD, editors. Principles and applications. Boca Raton: CRC Press, 2003.
  31. Hench LL, Bioceramics. J Am Ceram Soc 1998, 81:1705 ? 1728.
  32. Suchanek W, Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res 13,1998, 94 ? 117.
  33. Wojciech Suchanek, Masahiro Yoshimura, Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants, Journal of Materials Research, Publisher: Cambridge University Press (CUP), Volume: 13/1, 2011, 94-117.
  34. Amass W, Amass A, Tigle B, A review of biodegradable polymers: uses, current developments in the synthetic and characterization of biodegradable polyesters, blends of biodegradable polymers and recent advances in biodegradation studies, Polymer International 47,1998, 89 ? 144.
  35. Richard Song, Maxwell Murphy, Chenshuang Li, Kang Ting, Chia Soo, and Zhong Zheng, Current development of biodegradable polymeric materials for biomedical applications, Drug Des Devel Ther. 12: 2018, 3117?3145.
  36. Tencer AF, Mooney V, Brown KL, Silva PA, Compressive properties of polymer coated synthetic hydroxyapatite for bone grafting, J Biomed Mater Res 19,1985, 957 ? 969.
  37. F. Tencer V. Mooney K. L. Brown P. A. Silva, Compressive properties of polymer coated synthetic hydroxyapatite for bone grafting, https://doi.org/10.1002/jbm.820190807
  38. Lias B-P, Polymer in controlled drug delivery, Biomaterials, devicelink.com/mpb/archive/97/11/003.html.
  39. Brekke JH, A rational for delivery of osteoinductive proteins, Tissue Engineering, volume 2/ 2 ,1996, 97 ? 114.
  40. Ziyad S. Haidar, Reggie C. Hamdy, Maryam Tabrizian,Delivery of recombinant bone morphogenetic proteinsfor bone regeneration and repair. Part A: Current challenges in BMP delivery, Springer Science +Business Media B.V. 2009
  41. Ikada Y, Tsuji H, Biodegradable polyesters for medical and ecological applications, Macro mol Rapid Commun 21, 2000,117 ? 132.
  42. Peter SJ, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG, Polymer concepts in tissue engineering, J Biomed Mater Res Applied Biomaterials 43 ,1998, 422 ? 427.
  43. Naseer Iqbal, Abdul Samad Khan, Anila Asif, Muhammad Yar, John W. Haycock, & Ihtesham Ur Rehman, Recent concepts in biodegradable polymers for tissue engineering paradigms: a critical review, Journal International Materials Reviews, V. 64/2, 2018, 91-126
  44. Hutmacher DW, Schautz T, Zein I, Ng KW, Teoh SH, Tan KC, Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling, J Biomed Mater Res 55 ,2001, 203 ? 216.
  45. Marco Domingos, Dinuccio Dinucci, Stefania Cometa, Michele Alderighi, Paulo Jorge B?rtolo, and Federica Chiellini, Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications, International Journal of Biomaterials, 2009, Article ID 239643, 9 pages
  46. Lewis G, Mladsi S, Correlation between impact strength and fracture toughness of PMMA-based bone cement, Biomaterials 21, 2000, 775 ? 781.
  47. Bialoblocka, Juszczk, M. Baleani, L. Cristofolini, M. Viceconti, Fracture properties of an acrylic bone cement, Acta of Bioengineering and Biomechanics, Vol. 10, No. 1, 2008, 21-26.
  48. Rizzi SC, Heath DJ, Coombes AGA, Bocvk N, Textor M, Downes S, Biodegradable polymer / hydroxyapatite composites: surface analysis and initial attachment of human osteoblast, J Biomed. Mater Res 55, 2001, 575 ? 486.
  49. J. Heo, S.E. Kim, Y.T. Hyun, D.H. Kim, H.M. Lee, J.W. Shin1, Y.M. Hwang1, J.W. Shin1, Biodegradable composite of poly ˢ-caprolactone/hydroxyapatite 3-D scaffolds for bone tissue engineering, 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006, 672-675
  50. Zhong-Bei J, Min-li J, Feng-Wang Z, Chang-le J, Guo-Wang S, Polycaprolactone-poly(ethylene-glycol) block polymer IV: Biodegradable behavior in vitro and in vivo, Polymers for Advanced Technologies, volume 8, (1996) 693 ? 696.
  51. Haiying Yu, Paul H Wooley & Shang-You Yang, Biocompatibility of Poly-ε-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cells, Journal of Orthopaedic Surgery and Research volume 4, Article number: 5 (2009)
  52. Langstaff S, Sayer M, Smith TJN, Pugh SM, Hesp SAM, Thompson WT, Resorbable bioceramics based stabilized calcium phosphate, Part I: Rational design. Sample preparation and material characterization, Biomaterials 20(1999) 1727 ? 1741.
  53. Masanobu Kamitakahara, Chikara Ohtsuki, Toshiki Miyazaki, Review Paper: Behavior of Ceramic Biomaterials Derived from Tricalcium Phosphate in Physiological Condition, Journal of Biomedical Applications, Volume: 23/3, 2008 197-212.

[Tawfik Taher AJAAL (2019); OPTIMIZATION OF POLYMER TOUGHENING PROCESS OF SOLID HYDROXYAPATITE IMPLANT. Int. J. of Adv. Res. 7 (Oct). 128-140] (ISSN 2320-5407). www.journalijar.com


Tawfik Taher Ajaal
Professor

DOI:


Article DOI: 10.21474/IJAR01/9814      
DOI URL: http://dx.doi.org/10.21474/IJAR01/9814