Study of the Effects of Prunus Domestica L. Seeds on Some Blood Biochemical Parameters in Hypercholesterolemic Female Rats

Background: The present study investigate the effect extracts of Prunus Domestica red (PDR) and Prunus Domestica yellow (PDY) seeds on some biochemical parameters in hypercholesterolemic female rats. Materials and methods: Twenty four healthy female rats (Rattus norvegicus ) (mean weight, 220-250g) were divided into following four groups with 6 animals in each group, all rats in bio-chemical parameters are divided into normal control group (I), hypercholesterolemic positive control group (II), group (III) of hypercholesterolemic experimental rats received the PDR extract at 50 mg/kg of body weight for 20 days on daily basis. While group (IV) rats is received the PDY extract at 50 mg/kg of body weight for 20 days on daily basis. Whilst blood samples collects after 20days. Results: The results lipid profile showed a significant increase (P<0.05) in serum TC, TG, LDL,VLDL and Atherogenic Index levels between group (II) rats compared with normal control group (I). Serum HDL levels are a significant decreases in group (II) (P < 0.05) compared with normal control group (I). PDR and PDY extracts are significantly decreased in serum TC, TG, LDL,VLDL and Atherogenic Index levels between groups (III & IV) compared with group (II). PDR and PDY extracts are significantly increased in serum HDL between groups (III & IV) compared with group (II). Conclusion: The PDR extract reduces the lipid levels more effective than PDY extract.