27Jan 2020

A RARE OFUJI PAPULO-ERYTHRODERMA REVEALING A LANGERHANS CELL HISTIOCYTOSIS INVOLVING ONLY LYMPH NODES

  • Department of Dermatology, Mohammed VI University Hospital Center, Cadi Ayyad University, CHU Mohammed VI BP 2360 Principal Avenue Ibn Sina, Marrakech, Morocco
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Ofuji Papulo-erythroderma is a rare entity. Its origin is most often paraneoplasic: visceral neoplasias and blood diseases are the most frequently found. We report a case of Ofuji papuloerythroderma revealing langerhans cell histiocytosis involving only lymph nodes.We report the case of a 48-year-old man who presented a pruriginous papuloerythroderma, respecting skin folds, having progressed for 8 years in a context of deterioration of the general state, associated with bilateral inguinal lymphadenopathies. The patient had already had several skin biopsies that were inconclusive. The biological assessment revealed an inflammatory syndrome and a discreet hyper-eosinophilia. Lymph node biopsy confirmed the diagnosis of Langerhans cell histiocytosis. Clinical and imaging studies did not reveal abnormalities in other organs, concluding to isolated lymph node involvement by Langerhans cell histiocytosis. The patient received chemotherapy by vinblastine and corticosteroids with very good clinical progress. Lymph node involvement by Langerhans cell histiocytosis is rarely described in the literature, it is most often located in the drainage area of a cutaneous or bone lesion, and it is rarely isolated. Ofujis papulo-erythroderma is a rare entity, most often paraneoplastic and exceptionally associated with Langerhans cell histiocytosis, which needs a very thorough etiological assessment to determine the underlying etiology.


  1. Bagot and Revuz (1992). Faut-il individualiser la papulo-?rythrodermie dOfuji?Ann Dermatol Venerol, 119: 628.
  2. Farthing et al. (1986). Papuloerythroderma? a further case with the deck chair sign. Dermatologica, 172:65-66.
  3. Morgenfeld and Schajowicz (1971). Solitary eosinophilic granuloma of lymphnode: five-year follow-up. Pediatrics, 48:301- 5.
  4. Mutluer et al.(2004). Treatment of papuloerythroderma of Ofuji with Re-PUVA : a case report and reviewtherapy. J EurAcadDermatolVenereol, 18:480-483.
  5. N?el et al. (2015). Histiocytose langerhansienne de ladulte. La Revue de m?decine interne, 36:658?667.
  6. Ofuji et al. (1984). Papuloerythroderma. Dermatologica, 1984, 169:125?130.
  7. Thomsen (1998). Ofujispapulo erythroderma: a study of 17 cases. Clin Exp Dermatol, 23: 79?83.
  8. Torchia et al. (2010). Papuloerythroderma 2009 : two new cases and systemic review of the world wide literature 25 years after its identification by Ofuji et al. Dermatology, 220:311-320.
  9. Williams and Dorfman (1979). Lymphadenopathy as the initial manifestation of histiocytosis X. Am J Surg Pathol, 3:405-21.
  10. Edelweiss et al. (2007). Lymph node involvement by Langerhans cell histiocytosis: a clinico pathologic and immunohistochemical study of 20 cases. Human Pathology, 38:1463? 1469.
  11. Ruiz-Villaverde et al. (2014). Erythroderma as an Initial Presentation of Langerhans Cell Histiocytosis Involving the Sinus. Actas Dermo-Sifiliogr?ficas (English Edition), 105(Issue 6):630-2.

[Nafissa Farid, Said Amal and Ouafa Hocar (2020); A RARE OFUJI PAPULO-ERYTHRODERMA REVEALING A LANGERHANS CELL HISTIOCYTOSIS INVOLVING ONLY LYMPH NODES Int. J. of Adv. Res. 8 (1). 244-248] (ISSN 2320-5407). www.journalijar.com


Nafissa FARID
Department of Dermatology, Cadi Ayyad University, Mohammed VI University Hospital Center, Marrakech, Morocco.

DOI:


Article DOI: 10.21474/IJAR01/10290       DOI URL: http://dx.doi.org/10.21474/IJAR01/10290


Share this article