The Possible Protective Effects of Candesartan cilexetil Against Methoteraxte Induced Nephrototoxicity In Rabbits
Abstract: This study was designed to evaluate the possible protective effects of candesartan cilexetil against methoteraxte induced nephrotoxicity in rabbits . The animal groups were divided into a control group received tap water these animals were anesthetized by ether and then will be sacrificed on day 10. Methoteraxte (MTX) group (Induction group) received (100 mg /kg intraperitonealy a single dose at day 4 to induced nephrotoxicity. The animals were anesthetized by ether & then will be sacrificed on day 10 ,this group served as second positive control of renal damage . Candesartan + Methoteraxte (MTX) group (pre & post-group) in which rabbits treated with Candesartan10 mg /kg orally for 10 days & MTX 100 mg/kg a single dose intraperitonealy at day 4 , the animals were anesthetized by ether and then will be sacrificed on day 10. then estimation of serum levels of urea , creatinine ,albumin and total serum protein (TSP) . Also the kidney tissue homogenate was prepared to evaluate tissue levels of malondialdehyde (MDA) and glutathione (GSH) . Finally, kidney tissue sections were prepared by using paraffin sections technique and stained with hematoxylin and eiosin for histological evaluation .
[Tahssein Ali Mohammed, Adeeb A. Al-Zubaidy, Yarub I. Khattab, Hayder B Sahib (2014); The Possible Protective Effects of Candesartan cilexetil Against Methoteraxte Induced Nephrototoxicity In Rabbits Int. J. of Adv. Res. 2 (12). 0] (ISSN 2320-5407). www.journalijar.com
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