Chemopreventive effect of daidzein on renal toxicity by targeting oxidative stress and inflammation

Abstract: Flavonoid family is a rich source of polyphenolic compounds and hence possess strong antioxidant and anti inflammatory properties. The aim of this study was to determine the efficacy of Daidzein; a bio-active flavonoid as an anti-nephrotoxic agent. Several published reports advocate that supplementation with antioxidant can influence Fe-NTA induced renal damage. In the present study the wistar rats were subjected to concurrent prophylactic oral treatment of daidzein (25 and 50 mg/kg b.wt.) against the nephro-toxicity induced by intraperitoneal administration of Fe-NTA (9 mg Fe /kg b.wt.). Efficacy of chrysin against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, histopathological changes and expression / levels of molecular markers of inflammation. Daidzein ameliorated Fe-NTA-induced lipid peroxidation, xanthine oxidase activity, glutathione depletion, decrease in antioxidant (catalase, glutathione reductase, superoxide dismutase and glutathione peroxidase). Daidzein also attenuated expression of COX-2, i-NOS and levels of NF?B TNF-?, IL-6 and IL-1? and renal tissue damage which were induced by Fe-NTA. Histological findings also supported the protective effects of daidzein against Fe-NTA-induced renal damage. The results of the present study demonstrate that oxidative stress and inflammation are closely associated with Fe-NTA induced toxicity and chrysin shows the protective efficacy against Fe-NTA-induced renal toxicity possibly via attenuating the oxidative stress and inflammatory response.

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[Hiba Hazim Hamid Al-Yousuf (2015); Chemopreventive effect of daidzein on renal toxicity by targeting oxidative stress and inflammation Int. J. of Adv. Res. 3 (2). 0] (ISSN 2320-5407). www.journalijar.com

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