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Introduction: Fine needle aspiration of thyroid nodule is an important, sensitive and widely accepted method for diagnosing the thyroid lesions. The cytological features like cell pattern, cell morphology, intracytoplasmic vacuoles and background are important features in reaching the diagnosis. Marginal vacuoles are magenta coloured irregular cytoplasmic vacuoles seen at the periphery of follicular epithelial cells with unstained central areas on MGG stain. The present study was aimed to find out the significance of marginal vacuoles in FNAC of various thyroid lesions presenting as single thyroid nodule. Patients and Methods: This study was done on 46 patients presented with solitary thyroid nodule. The various cytomorphological features along with presence of marginal vacuoles were studied. Results: Significant marginal vacuoles were seen in thyrotoxic goiter patients (100%) followed by patients with hyperplastic nodule (75%). Autoimmune thyroiditis (50%) and Follicular Neoplasm (31.5%) cases also showed presence of grade II and grade-III marginal vacuoles in significant number of cases. None of the colloid goiter case had grade-II + grade-III marginal vacuoles.
[Manisha Sharma, Manas Madan, Tejinder Singh Bhasin, Mridu Manjari, Sanjay Piplani, Harjot Kaur, Manpreet Kaur, Rajneesh Salwan (2015); Marginal vacuoles in thyroid lesions: A cytomorphological Study on Fine needle aspiration. Int. J. of Adv. Res. 3 (2). 0] (ISSN 2320-5407). www.journalijar.com
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