Novel Aminated Chitosan-Aromatic Aldehydes Schiff Bases: Synthesis, Characterization and Bio-evaluation
Abstract: Novel aminated chitosan-aromatic aldehyde Schiff bases have been synthesized, characterized and finally their antimicrobial activities were evaluated. P-hydroxy benzaldehyde and vanillin were reacted with aminated chitosan via the original and the introduced amino groups. The chemical structure of the obtained Schiff bases was verified through elemental analysis, IR spectroscopy, 1HNMR spectra and TGA. The following microorganisms were chosen to test the antimicrobial activity of the synthesized polymers, the Gram-negative bacterium (Escherichia coli (NCIM 2065), Salmonela typhi, and Pseudomonas aeruginosa), and the Gram-positive bacterium (Staphylococcus aureus). Moreover, the fungi (C. albicans (SC5314), Cryptococcus neoformans, Aspergillus flavus and Aspergillus niger) were used. The antimicrobial activity of aminated chitosan on fungi, Gram-positive bacteria, and Gram-negative bacteria show small inhibitory effect against fungi species, an increase in the inhibition of Gram-negative more than Gram-positive bacteria is observed. Aminated chitosan modified with p-hydroxy benzaldehyde and aminated chitosan modified with vanillin showed small inhibit effect against fungi species, however they shows a higher inhibitory effect against a wide variety of Gram-positive bacteria and Gram-negative bacteria. Diameter of inhibition zones were ranged between 9-17 mm on Gram-negative bacteria, 18 mm on Gram-positive bacteria.
[El-Refaie Kenawy, F. Imam Abdel-Hay, M. S. Mohy Eldin, T. M. Tamer and Enaam M. Abo-Elghit Ibrahim (2015); Novel Aminated Chitosan-Aromatic Aldehydes Schiff Bases: Synthesis, Characterization and Bio-evaluation Int. J. of Adv. Res. 3 (2). 0] (ISSN 2320-5407). www.journalijar.com
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