A comparison of propofol induction dose requirement for induction in patient with supratentorial brain tumor and patients without intracranial tumor

Aim:-To compare the propofol induction dose requirement haemodynamic effects in patients having intracranial tumour with non intracranial tumour patients. Method: - 100 patients in each group were taken in this prospective, randomized study. Either of a 4 dose of Propofol (0.5, 1, 1.5, or 2.0 mg/kg) was given in induction. After 2 minutes of propofol given, 10s, 50 HZ, 80 ma transcutaneous tetanic current was given to the ulnar nerve as a test for response to painful stimuli. Any abnormal body movements were noted as a positive response. Haemodynamic data were observed for 2 minutes. Results:- Mean induction dose of propofol was required to abolish the tetanic painful stimuli was0.88+/- 0.51mg/kg in Group T and 1.92+/-3.66 mg/kg in Group C. Propofol dose was significantly less required in large tumour(>30mm) than smaller tumour patients. 55 (55%) patients with large tumor were induced with 1mg/kg in group T while it was 1% in Group C. Out of this 55 patients, 41(74.5%) were of large tumor and 14(24.5%) were small tumour patients. 33% of patients were induced with 1.5 mg/kg in Group T. In Group C, 84 patients were required large dose (2mg/kg) compared to 2 patients in Group T. Conclusion: - There is a less dose requirement of Propofol during anaesthesia induction in patients of supratentorial mass lesion especially having a tumour of larger (>30mm) size.